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Life Science Products

Reagents, Lab Equipment, Lab Supplies, and Contract Services

Working together with the Nippi Research Institute of Biomatrix, the Biological and Chemical Products Division is responsible for creating innovative basic and applied scientific products such as collagen, laminin, and related products. Our clean room facility also enables us to manufacture reliable, high-quality medical and scientific products.

We distribute various kinds of collagen as reagents, such as a highly purified gelatin MediGelatinR for medical use, and "NippiBLR BSE Test Kit" for diagnosis of BSE. In addition, we offer contracted protein analysis for academic and industrial laboratories. We have also developed original laboratory devices that are widely accepted domestically and globally, such as the "BioMasherR". The Biological and Chemical Products Division continuously aims to contribute globally with our cutting edge research and innovative, quality development.

Reagents,Lab Equipment,Supplies,and Contract Services
Collagen

Collagen

Collagen is the most abundant protein in our body, about 30% of total protein. Collagen is rich in bone, skin, tendon, ligament, cartilage, heart, eye, and so on. Synthesis of collagen protein is one of the most complicated process among the all human proteins. Many enzymatically posttranslational modifications involve the synthesis such as 3- and 4-hydroxyproline and 5-hydroxylysine. Some of hydroxylysine residues are additionally modified as galactosylhydroxylysine and glucosylgalactosylhydroxylysine. 4-Hydroxylation of proline increases the thermal stability of triple helical structure. These posttranslational modification reactions are essential to the biological function. Defection of these enzymes causes abnormality in bone and other organs. Due to the many posttranslational modifications and the large size of molecule, it is impossible to produce collagen molecules from recombinant expression with reasonable prices. With Nippi’s more than a half century of research expertise, we produce purified collagen from various kinds of animal tissues such as skin, tendon, lens capsule, and cartilage. Bovine, porcine, chick, tilapia are some of the animal sources. Product forms are solution, powder, or sheets of reconstituted fibrils. Types I, III, and IV collagens are on our catalog list. We also accept custom orders for other types and/or from other animal sources. Please contact us if you need specific types of collagen, or if you would like to order in bulk.

Low Endotoxin Gelatin

Low Endotoxin Gelatin

Gelatin is the denatured form of collagen protein. We have medical grade collagen with a very low content of endotoxin (≦10 EU/gram). Nippi’s MediGelatin? has almost an intact size of the collagen alpha chain, and Nippi’s High Grade Gelatin has a little smaller polypeptide sizes with MW of 60K and 8K on average. Nippi’s technology enables the purification of high-grade gelatin.

Laminin

Laminin

Laminin is the major component of basement membrane. Our iMatrix-511, the E8 fragment of laminin-511 protein, has been widely used as the substrates for pluripotent stem cell culture. One of the major benefits of our short fragment laminin is the ability for the single cell passaging of iPS/ES cells.

Lab Equipment and Supplies

Lab Equipment and Supplies

BioMasher is a single-use homogenizer for nucleic acid extraction, protein extraction, and cell disruption. We have a battery powered motor, PowerMasher, designed for BioMasher, long tips, and racks, etc.

Other reagents

Other reagents

From 1996, we have collaborated with National Institute of Animal Health and the National Agriculture and Food Research Organization to study prion protein. We developed a highly sensitive BSE test kit. Our kit has been widely used all over Japan.

BSE(Bovine Spongiform Encephalopathy)test kit

Contract Services

We offer two contracted services for scientific researches: N-terminal peptide sequencing and peptide synthesis. Please contact us for more details.

Contract Services

BSE(Bovine Spongiform Encephalopathy)test kit

From 1996, we have collaborated with National Institute of Animal Health and the National Agriculture and Food Research Organization to study prion protein. We developed a highly sensitive BSE test kit. Our kit has been widely used all over Japan.

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