Fujisaki H, Futaki S, Mizuno K, Hattori S. Evaluation of Keratinocyte Proliferation on Two- and Three-Dimensional Type I Collagen Substrates. JoVE Submission ID #: 59339 (2019) Link 

Sato K, Jimi S, Kusubata M. Generation of bioactive prolyl-hydroxyproline (Pro-Hyp) by oral administration of collagen hydrolysate and degradation of endogenous collagen and ingestion of collagen hydrolysate. Int J Food Sci Technol (2019) in press

Yang J, Sun Y, Xu F, Liu W, Hayashi T, Hattori S, Ushiki-Kaku Y, Onodera S, Tashiro SI, Ikejima T1. Silibinin protects rat pancreatic β-cell through up-regulation of estrogen receptors' signaling against amylin- or Aβ1-42 -induced reactive oxygen species/reactive nitrogen species generation. Phytother Res. 2019 Feb 6. doi: 10.1002/ptr.6293. [Epub ahead of print] PubMed PMID: 30729588.

Yang J, Sun Y, Xu F, Liu W, Mai Y, Hayashi T, Hattori S, Ushiki-Kaku Y, Onodera S, Tashiro SI, Ikejima T. Silibinin ameliorates amylin-induced pancreatic β-cell apoptosis partly via upregulation of GLP-1R/PKA pathway. Mol Cell Biochem. 2019 Feb;452(1-2):83-94. doi: 10.1007/s11010-018-3414-9. Epub 2018 Jul 18. PubMed PMID: 30022448.

Xu Q, Liu X, Liu W, Hayashi T, Yamato M, Fujisaki H, Hattori S, Tashiro SI, Onodera S, Ikejima T. Type I collagen-induced YAP nuclear expression promotes primary cilia growth and contributes to cell migration in confluent mouse embryo fibroblast 3T3-L1 cells. Mol Cell Biochem. 2019 Jan;450(1-2):87-96. doi: 10.1007/s11010-018-3375-z. Epub 2018 May 30. PubMed PMID: 29846859; PubMed Central PMCID: PMC6168687.

Kumazawa Y, Hattori S, Taga Y. Semi-nondestructive certification of crocodilian leather by LC-MS detection of collagen marker peptides. Anal Chem. 2019 Jan 1. doi: 10.1021/acs.analchem.8b05180. PubMed PMID: 30599131.

Saito S, Sano K, Suzuki T, Ainai A, Taga Y, Ueno T, Tabata K, Saito K, Wada Y, Ohara Y, Takeyama H, Odagiri T, Kageyama T, Ogawa-Goto K, Multihartina P, Setiawaty V, Pangesti KNA, Hasegawa H. IgA tetramerization improves target breadth but not peak potency of functionality of anti-influenza virus broadly neutralizing antibody. PLoS Pathog. 2019 Jan 3;15(1):e1007427. doi: 10.1371/journal.ppat.1007427. eCollection 2019 Jan. PubMed PMID: 30605488; PubMed Central PMCID: PMC6317788.


Taga Y, Kusubata M, Ogawa-Goto K, Hattori S, Funato N. Collagen-derived X-Hyp-Gly-type tripeptides promote differentiation of MC3T3-E1 pre-osteoblasts. J. Funct. Foods, 46, 456-462 (2018)

Kumazawa Y, Taga Y, Takashima M, Hattori S. A novel LC–MS method using collagen marker peptides for species identification of glue applicable to samples with multiple animal origins. Herit. Sci., 6, 43 (2018)

Tanaka K, Teramura N, Hayashida O, Iijima K, Okitsu T, Hattori S. The C-terminal segment of collagenase in Grimontia hollisae binds collagen to enhance collagenolysis. FEBS Open Bio. 2018 Sep 6;8(10):1691-1702. doi: 10.1002/2211-5463.12510. eCollection 2018 Oct. PubMed PMID: 30338219; PubMed Central PMCID: PMC6168687.

Caviness P, Bauer R, Tanaka K, Janowska K, Roeser JR, Harter D, Sanders J, Ruth C, Matsushita O, Sakon J. Ca(2+) -induced orientation of tandem collagen binding domains from clostridial collagenase ColG permits two opposing functions of collagen fibril formation and retardation. FEBS J. 2018 Sep;285(17):3254-3269. doi: 10.1111/febs.14611. Epub 2018 Aug 20. PubMed PMID: 30035850; PubMed Central PMCID: PMC6126967.

Terauchi Y, Sano K, Ainai A, Saito S, Taga Y, Ogawa-Goto K, Tamura SI, Odagiri T, Tashiro M, Fujieda M, Suzuki T, Hasegawa H. IgA polymerization contributes to efficient virus neutralization on human upper respiratory mucosa after intranasal inactivated influenza vaccine administration. Hum Vaccin Immunother. 2018 Jun 3;14(6):1351-1361. doi: 10.1080/21645515.2018.1438791. Epub 2018 Apr 9. PubMed PMID: 29425074; PubMed Central PMCID: PMC6037454.

Zhao YL, Zhang X, Liu WW, Yang YT, Gao ZK, Liu XL, Liu W, Hayashi T, Yamato M, Fujisaki H, Hattori S, Mizuno K, Atsuzawa Y, Tashiro SI, Onodera S, Ikejima T. Reactive oxygen species are responsible for the cell aggregation and production of pro-inflammatory mediators in phorbol ester (PMA)-treated U937 cells on gelatin-coated dishes through upregulation of autophagy. Connect Tissue Res. 2018 Oct 2. doi: 10.1080/03008207.2018.1530770. [Epub ahead of print] PubMed PMID: 30277081.

Fujisaki H, Futaki S, Yamada M, Sekiguchi K, Hayashi T, Ikejima T, Hattori S. Respective optimal calcium concentrations for proliferation on type I collagen fibrils in two keratinocyte line cells, HaCaT and FEPE1L-8. Regen Ther. 2018 May 24;8:73-79. doi: 10.1016/j.reth.2018.04.001. eCollection 2018 Jun. PubMed PMID: 30271869.

Taga Y, Hayashida O, Ashour A, Amen Y, Kusubata M, Ogawa-Goto K, Shimizu K, Hattori S. Characterization of Angiotensin-Converting Enzyme Inhibitory Activity of X-Hyp-Gly-Type Tripeptides: Importance of Collagen-Specific Prolyl Hydroxylation. J Agric Food Chem. 2018 Aug 22;66(33):8737-8743. doi: 10.1021/acs.jafc.8b03648. Epub 2018 Aug 13. PubMed PMID: 30060651.

Yang J, Sun Y, Xu F, Liu W, Mai Y, Hayashi T, Hattori S, Ushiki-Kaku Y, Onodera S, Tashiro SI, Ikejima T. Silibinin ameliorates amylin-induced pancreatic β-cell apoptosis partly via upregulation of GLP-1R/PKA pathway. Mol Cell Biochem. 2018 Jul 18. doi: 10.1007/s11010-018-3414-9. PubMed PMID: 30022448.

Liu X, Xu Q, Long X, Liu W, Zhao Y, Hayashi T, Hattori S, Fujisaki H, Ogura T, Tashiro SI, Onodera S, Yamato M, Ikejima T. Silibinin-induced autophagy mediated by PPARα-sirt1-AMPK pathway participated in the regulation of type Icollagen-enhanced migration in murine 3T3-L1 preadipocytes. Mol Cell Biochem. 2018 Jun 18. doi: 10.1007/s11010-018-3368-y. [Epub ahead of print] PubMed PMID: 29916120.

Xu Q, Liu X, Liu W, Hayashi T, Yamato M, Fujisaki H, Hattori S, Tashiro SI, Onodera S, Ikejima T. Type I collagen-induced YAP nuclear expression promotes primary cilia growth and contributes to cell migration in confluent mouse embryo fibroblast 3T3-L1 cells. Mol Cell Biochem. 2019 Jan;450(1-2):87-96. doi: 10.1007/s11010-018-3375-z. Epub 2018 May 30. PubMed PMID: 29846859.

Liu X, Long X, Liu W, Zhao Y, Hayashi T, Yamato M, Mizuno K, Fujisaki H, Hattori S, Tashiro SI, Ogura T, Atsuzawa Y, Ikejima T. Type I collagen induces mesenchymal cell differentiation into myofibroblasts through YAP-induced TGF-β1 activation. Biochimie. 2018 150:110-130. PubMed PMID: 29777737.

Liu X, Long X, Liu W, Yao G, Zhao Y, Hayashi T, Hattori S, Fujisaki H, Ogura T, Tashiro SI, Onodera S, Yamato M, Ikejima T. Differential levels of reactive oxygen species in murine preadipocyte 3T3-L1 cells cultured on type I collagen molecule-coated and gel-covered dishes exert opposite effects on NF-κB-mediated proliferation and migration. Free Radic Res. 2018 [Epub ahead of print] PubMed PMID: 29768932.

Song X, Liu B, Cui L, Zhou B, Liu L, Liu W, Yao G, Xia M, Hayashi T, Hattori S, Ushiki-Kaku Y, Tashiro SI, Ikejima T. Estrogen Receptors Are Involved in the Neuroprotective Effect of Silibinin in Aβ(1-42)-Treated Rats. Neurochem Res. 2018 43:796-805. PubMed PMID: 29397533.

Nishikimi A, Koyama YI, Ishihara S, Kobayashi S, Tometsuka C, Kusubata M, Kuwaba K, Hayashida O, Hattori S, Katagiri K. Collagen-derived peptides modulate CD4(+) T-cell differentiation and suppress allergic responses in mice. Immun Inflamm Dis. 2018 Jun;6(2):245-255. doi: 10.1002/iid3.213. Epub 2018 Feb 1. PubMed PMID: 29388365.

Yamauchi M, Taga Y, Hattori S, Shiiba M, Terajima M. Analysis of collagen and elastin cross-links. Methods Cell Biol. 2018 143:115-132 PMID: 29310773

Liu X, Xu Q, Liu W, Yao G, Zhao Y, Xu F, Hayashi T, Fujisaki H, Hattori S, Tashiro SI, Onodera S, Yamato M, Ikejima T. Enhanced migration of murine fibroblast-like 3T3-L1 preadipocytes on type I collagen-coated dish is reversed by silibinin treatment. Mol Cell Biochem. 2018 441:35-62. PMID: 28933025

Xu Q, Liu W, Liu X, Otkur W, Hayashi T, Yamato M, Fujisaki H, Hattori S, Tashiro SI, Ikejima T. Type I collagen promotes primary cilia growth through down-regulating HDAC6-mediated autophagy in confluent mouse embryo fibroblast 3T3-L1 cells. J Biosci Bioeng. 2018 Jan;125(1):8-14. PMID: 28811097

Zhao YL, Lu ZY, Zhang X, Liu WW, Yao GD, Liu XL, Liu W, Wu QJ, Hayashi T, Yamato M, Fujisaki H, Hattori S, Atsuzawa Y, Tashiro SI, Onodera S, Ikejima T. Gelatin promotes cell aggregation and pro-inflammatory cytokine production in PMA-stimulated U937 cells by augmenting endocytosis-autophagy pathway. Int J Biochem Cell Biol. 2018 95:132-142 PMID: 29307663

Kuwaba K, Koyama Y.-I, Hayashida O, Kusubata M, Takara T, Tsukada Y. Safety Evaluation of Collagen Peptide Ingestion -Randomized, Placebo-controlled, Double-blind, Parallel-group Trial. Jpn Pharmacol Ther 46, 1859-1870 (2018)


Zhao YL, Lu ZY, Zhang X, Liu WW, Yao GD, Liu XL, Liu W, Wu QJ, Hayashi T, Yamato M, Fujisaki H, Hattori S, Atsuzawa Y, Tashiro SI, Onodera S, Ikejima T. Gelatin promotes cell aggregation and pro-inflammatory cytokine production in PMA-stimulated U937 cells by augmenting endocytosis-autophagy pathway. Int J Biochem Cell Biol. 2018 95:132-142 PMID: 29307663

Ishikawa Y, Mizuno K, Bächinger HP. Ziploc-ing the structure 2.0: Endoplasmic reticulum-resident peptidyl prolyl isomerases show different activities toward hydroxyproline. J Biol Chem. 2017 292:9273-9282. PMID: 28385890

Zhao YL, Liu WW, Liu W, Lu ZY, Xuan DH, Zhang X, Liu XL, Hayashi T, Yamato M, Ogura T, Fujisaki H, Hattori S, Tashiro SI, Onodera S, Ikejima T. Phorbol ester (PMA)-treated U937 cells cultured on type I collagen-coated dish express a lower production of pro-inflammatory cytokines through lowered ROS levels in parallel with cell aggregate formation. Int Immunopharmacol. 2017 55:158-164. PMID: 29253822

Taga Y, Kusubata M, Ogawa-Goto K, Hattori S. Identification of Collagen-Derived Hydroxyproline (Hyp)-Containing Cyclic Dipeptides with High Oral Bioavailability: Efficient Formation of Cyclo(X-Hyp) from X-Hyp-Gly-Type Tripeptides by Heating. J Agric Food Chem. 2017 65:9514-9521. PMID: 28988478

Taga Y, Tanaka K, Hamada C, Kusubata M, Ogawa-Goto K, Hattori S. Hydroxyhomocitrulline Is a Collagen-Specific Carbamylation Mark that Affects Cross-link Formation. Cell Chem Biol. 2017 24:1276-1284.e3. PMID: 28943354

Song X, Liu B, Cui L, Zhou B, Liu W, Xu F, Hayashi T, Hattori S, Ushiki-Kaku Y, Tashiro SI, Ikejima T. Silibinin ameliorates anxiety/depression-like behaviors in amyloid β-treated rats by upregulating BDNF/TrkB pathway and attenuating autophagy in hippocampus. Physiol Behav. 2017 179:487-493. PMID: 28735062

Terajima M, Taga Y, Cabral WA, Nagasawa M, Sumida N, Hattori S, Marini JC, Yamauchi M. Cyclophilin B Deficiency Causes Abnormal Dentin Collagen Matrix. J Proteome Res. 2017 16:2914-2923. PMID: 28696707

Taga Y, Hayashida O, Kusubata M, Ogawa-Goto K, Hattori S. Production of a novel wheat gluten hydrolysate containing dipeptidyl peptidase-IV inhibitory tripeptides using ginger protease. Biosci Biotechnol Biochem. 2017 81:1823-1828. PMID: 28675098

Nakayama H, Mori M, Takita T, Yasukawa K, Tanaka K, Hattori S, Aikawa H, Hasegawa O, Okamura T, Takegami K, Motokawa S, Kuwahara M, Amano K. Development of immersion vaccine for bacterial cold-water disease in ayu Plecoglossus altivelis. Biosci Biotechnol Biochem. 2017 81:608-613. PMID: 28051913

Song X, Zhou B, Cui L, Lei D, Zhang P, Yao G, Xia M, Hayashi T, Hattori S, Ushiki-Kaku Y, Tashiro SI, Onodera S, Ikejima T. Silibinin ameliorates Aβ25-35-induced memory deficits in rats by modulating autophagy and attenuating neuroinflammation as well as oxidative stress. Neurochem Res. 2017 42:1073-1083. PMID: 28004303

Qian J, Ito S, Satoh J, Geng H, Tanaka K, Hattori S, Kojima K, Takita T, Yasukawa K. The cleavage site preference of the porcine pepsin on the N-terminal α1 chain of bovine type I collagen: a focal analysis with mass spectrometry. Biosci Biotechnol Biochem. 2017 81:514-522. PMID: 27931164

Wang HJ, Li MQ, Liu WW, Hayashi T, Fujisaki H, Hattori S, Tashiro SI, Onodera S, Ikejima T. Collagen gel protects L929 cells from TNFα-induced death by activating NF-κB. Connect Tissue Res. 2017 58:456-463. PMID: 27764545

Tometsuka C, Koyama YI, Ishijima T, Toyoda T, Teranishi M, Takehana K, Abe K, Nakai Y. Collagen peptide ingestion alters lipid metabolism-related gene expression and the unfolded protein response in mouse liver. Br J Nutr. 2017 117:1-11. PMID: 28091360


Qian J, Okada Y, Ogura T, Tanaka K, Hattori S, Ito S, Satoh J, Takita T, Yasukawa K. Kinetic analysis of the digestion of bovine type I collagen telopeptides with porcine pepsin. J Food Sci. (2016) 81(1): C27-34 [PubMed]

Taga Y, Kusubata M, Ogawa-Goto K, Hattori S. Developmental stage-dependent regulation of prolyl 3-hydroxylation in tendon type I collagen. J. Biol. Chem., (2016) 291:837-847

Kumazawa Y, Taga Y, Iwai K, Koyama Y. A Rapid and Simple LC-MS Method Using Collagen Marker Peptides for Identification of the Animal Source of Leather. J Agric Food Chem. 2016 Aug 3;64(30):6051-7. doi: 10.1021/acs.jafc.6b02132. Epub 2016 Jul 20. PubMed PMID: 27397145.

Sekiguchi H, Uchida K, Inoue G, Matsushita O, Saito W, Aikawa J, Tanaka K, Fujimaki H, Miyagi M, Takaso M. Acceleration of bone formation during fracture healing by poly(Pro-Hyp-Gly)10 and basic fibroblast growth factor containing polycystic kidney disease and collagen-binding domains from Clostridium histolyticum collagenase. J Biomed Mater Res A. (2016) 104(6):1372-8 [PubMed]


Nakayama H, Tanaka K, Teramura N, Hattori S. Expression of collagenase in Flavobacterium psychrophilum isolated from cold-water disease-affected ayu (Plecoglossus altivelis). Biosci Biotechnol Biochem. (2015) 80(1): 135-44

Hirose T, Ogura T, Tanaka K, Minaguchi J, Yamauchi T, Fukada T, Koyama Y, Takehana K. Comparative study of dermal components and plasma TGF-β1 levels in Slc39a13/Zip13-KO mice. J Vet Med Sci. (2015) 77(11): 1385-9

Watanabe T, Nishimura K, Takeuchi R, Koyama Y, Kusubata M, Takehana K, Hiramatsu K. Oral ingestion of collagen peptide causes change in width of the perimysium of the chicken iliotibialis lateralis muscle. J Vet Med Sci (2015) 77(11):1413-1417

Terao K, Kanenaga R, Yoshida T, Mizuno K, Bächinger HP. Temperature induced complex formation-deformation behavior of collagen model peptides and polyelectrolytes in aqueous solution. Polymer, (2015) 64:8-13

Koyama Y, Kuwaba K, Kusubata M, Hayashida O, Takara T, Tsukada Y. Supplemental ingestion of collagen peptide improves T-cell-related human immune status. Jap Pharmacol Ther 43:51-56 (2015)

Ohno M, Ito K, Lan VT, Kusubata M, Tometsuka C, Koyama Y, Motoyama T, Ito S, Kawarasaki Y. Synergistic inhibition of human dipeptidyl peptidase IV by combinations of peptides. Peptides. 2015 Jul; 69:115-7. doi: 10.1016/j.peptides.2015.04.015. Epub 2015 Apr 28. PubMed PMID: 25929171.

Kusubata M, Koyama Y, Tometsuka C, Shigemura Y, Sato K. Detection of endogenous and food-derived collagen dipeptide prolylhydroxyproline (Pro-Hyp) in allergic dermatitis-affected mouse ear. Biosci Biotechnol Biochem 79:1356-61 [PubMed]

Kobayashi, K., Maehata, Y., Okada, Y., Kusubata, M., Hattori, S., Tanaka, K., Miyamoto, C., Yoshino, F., Yoshida, A., Tokutomi, F., Wada-Takahashi, S, Komatsu, T., Otsuka, T., Takahashi, S., Lee, M. Medical-grade collagen peptide in injectables provides antioxidant protection. Pharm. Dev. Technol. (2015) 20: 219-226.

Wang HJ, He WQ, Chen L, Liu WW, Xu Q, Xia MY, Hayashi T, Fujisaki H, Hattori S, Tashiro S, Onodera S, Ikejima T. Type I collagen gel protects murine fibrosarcoma L929 cells from TNFα-induced cell death. Biochem Biophys Res Commun. (2015) 457:693-699


Iijima K, Sasaki M, Taga Y, Hattori S. Cross conversion between Nω-carboxymethylarginine (CMA) and glyoxal derived hydroimidazolones (G-Hs). IMARS Highlights., (2014) 9:29-36 [link]

Noritake, K., Kuroda, S., Nyan, M., Atsuzawa, Y., Uo, M., Ohya, K., Kasugai, S. Use of a gelatin hydrogel membrane containing β-tricalcium phosphate for guided bone regeneration enhances rapid bone formation. Dent Mater J. (2014) 33: 674-80

Taga Y, Kusubata M, Ogawa-Goto K, Hattori S. Highly accurate quantification of hydroxyproline-containing peptides in blood using a protease digest of stable isotope-labeled collagen. J. Agric. Food Chem., (2014) 62:12096-102

Taga Y, Kusubata M, Ogawa-Goto K, Hattori S. Stable isotope-labeled collagen: a novel and versatile tool for quantitative collagen analyses using mass spectrometry. J. Proteome Res, (2014) 13: 3671-78

Koyama Y, Kuwaba K, Kondo S, Tsukada Y. Supplemental ingestion of collagen peptide suppresses ultraviolet-induced erythema. – a randomized double-blind placebo-controlled study –. Jap Pharmacol Ther (2014) 42:781-790

Shibuya S, Ozawa Y, Toda T, Watanabe K, Tometsuka C, Ogura T, Koyama Y, Shimizu T. Collagen peptide and vitamin C additively attenuate age-related skin atrophy in Sod1-deficient mice. Biosci Biotechnol Biochem (2014) 78:1212-1220

Saito, W, Uchida, K., Ueno, M, Matsushita, O, Inoue, G, Nishi, N, Ogura, T, Hattori, S, Fujimaki, H., Tanaka, K, Takaso, M. Acceleration of bone formation during fracture healing by injectable collagen powder and human basic fibroblast growth factor containing a collagen-binding domain from Clostridium histolyticum collagenase. J Biomed Mater Res A., (2014) 102:3049-55 [PubMed]

Uchida, K., Matsushita, O., Naruse, K., Mima, T., Nishi, N., Hattori, S., Ogura, T., Inoue, G., Tanaka, K., Takaso, M. Acceleration of periosteal bone formation by human basic fibroblast growth factor containing a collagen-binding domain from Clostridium histolyticum collagenase. J Biomed Mater Res A., (2014) 102:1737-43 [PubMed]

Shibuya S, Ozawa Y, Toda T, Watanabe K, Tometsuka C, Ogura T, Koyama Y, and Shimizu T. Collagen Peptide and Vitamin C Additively Attenuate Age-Related Skin Atrophy in Sod1-Deficient Mice. Biosci. Biotechnol. Biochem. (2014) 78:1212-20 [PubMed]


Taga Y, Kusubata M, Ogawa-Goto K, Hattori S. Site-specific quantitative analysis of overglycosylation of collagen in osteogenesis imperfecta using hydrazide chemistry and SILAC. J Proteome. Res., (2013) 12: 2225-32

Ushiki-Kaku Y, Shimizu Y, Tabeta N, Iwamaru Y, Ogawa-Goto K, Hattori S, Yokoyama T. Heterogeneity of abnormal prion protein (PrPSc) in murine scrapie prions determined by PrPSc-specific monoclonal antibodies. J Vet Med Sci., (2013) 76:285-288

Ushiki-Kaku Y, Iwamaru Y, Masujin K, Imamura M, Itohara S, Ogawa-Goto K, Hattori S, Yokoyama T. Different antigenicities of the N-terminal region of cellular and scrapie prion proteins. Microbiol Immunol., (2013) 57:792-6

Yamamoto T, Ushiki-Kaku Y, Yokoyama T, Hattori S. Sensitivity and specificity of a commercial BSE kit for the detection of ovine scrapie. Anim Sci J., (2013) 84:508-12

Pokidysheva E, Zientek KD, Ishikawa Y, Mizuno K, Vranka JA, Montgomery NT, Keene DR, Kawaguchi T, Okuyama K, Bächinger HP. Posttranslational modifications in type I collagen from different tissues extracted from wild type and prolyl 3-hydroxylase 1 null mice. J Biol Chem., (2013) 288:24742-52

Okuyama K, Kawaguchi T, Shimura M, Noguchi K, Mizuno K, Bächinger HP. Crystal structure of the collagen model peptide (Pro-Pro-Gly)4-Hyp-Asp-Gly- (Pro-Pro-Gly)4 at 1.0 Å resolution. Biopolymers, (2013) 99:436-47

Mizuno K, Boudko S, Engel J, Bächinger HP. Vascular Ehlers-Danlos syndrome mutations in type III collagen differently stall the triple helical folding. J Biol Chem., (2013) 288:19166-76

Koyama Y and Kusubata, M. Effects of Collagen Peptide Ingestion on Blood Lipids in Rats Fed a High-Lipid and High-Sucrose Diet. Food Sci. Technol. Res. 19(6):1149-1153 (2013)

Yuda,Y., Kasashima, Y., Kuwano, A., Sato , K., Hattori, S. and Arai, K. Active Hyaluronidase 2 Expression in the Granulation Tissue Formed in the Healing Process of Equine Superficial Digital Flexor Tendonitis (note)—.The Journal of Veterinary Medical Science 75:219–223 (2013)


Ogawa-Goto K, Ueno T, Oshima K, Yamamoto H, Sasaki J, Fujita K, Sata T, Taniguchi S, Kanda Y, Katano H. Detection of Active Human Cytomegalovirus by the Promyelocytic Leukemia Body Assay in Cultures of PBMCs From Patients Undergoing Hematopoietic Stem Cell Transplantation. J Med Virol 84:479-486 (2012)

Yamamoto T, Nakashima K, Maruta Y, Kiriyama T, Sasaki M, Sugiyama S, Suzuki K, Fujisaki H, Sasaki J, Kaku UY, Tanida M, Irie S, Hattori S. Improved RNA Extraction Method Using the BioMasher and BioMasher Power-Plus. J Vet. Med. Sci. 74:1561-67 (2012)

Takahashi T, Kondo T, Tanaka K, Hattori S, Irie S, Kudoh S, Imura S, Kanda H. Measurement of solar UV radiation in Antarctica with collagen sheets. Photochem Photobiol Sci. 11(7):1193-200 (2012)

Ueno T, Kaneko K, Sata T, Hattori S, Ogawa-Goto K. "Regulation of polysome assembly on the endoplasmic reticulum by a coiled-coil protein, p180. Nucleic Acids Res. 40(7): 3006-3017 (2012)

Taga Y, Kusubata M, Ogawa-Goto K, Hattori S. Development of a novel method for analyzing collagen O-glycosylations by hydrazide chemistry. Mol Cell Proteomics. 11(6): M111 010397 (2012)


Teramura N, Tanaka K, Iijima K, Hayashida O, Suzuki K, Hattori S, Irie S. Cloning of a novel collagenase gene from Gram-negative bacterium Grimontia (Vibrio) hollisae 1706B and its efficient expression in Brevibacillus choshinensis. J Bacteriol. 193:3049-56 (2011)

Kobayashi K, Maehata Y, Kawamura Y, Kusubata M, Hattori S, Tanaka K, Miyamoto C, Yoshino F, Yoshida A, Wada-Takahashi S, Komatsu T, Takahashi SS, Lee MC. Direct assessments of the antioxidant effect of the novel collagen peptide on reactive oxygen species using electron spin resonance spectroscopy. J Pharmacol Sci. 116: 97-106 (2011)

Ueno T, Kaneko K, Sata T, Hattori S, Ogawa-Goto K. Regulation of polysome assembly on the endoplasmic reticulum by a coiled-coil protein, p180. Nucleic Acids Res. (2011)

Sasaki J, Fujisaki H, Adachi E, Irie S, Hattori S. Delay of cell cycle progression and induction of death of cancer cells on type I collagen fibrils. Connect Tissue Res. (2011)


omonori Ueno, Keisuke Tanaka, Keiko Kaneko, Yuki Taga, Tetsutaro Sata, Shinkichi Irie, Shunji Hattori, Kiyoko Ogawa-Goto. Enhancement of procollagen biosynthesis by p180 through augmented ribosome association on the endoplasmic reticulum in response to stimulated secretion. Journal of Biological Chemistry, 285, 29941-29950, (2010)

Ushiki-Kaku Y, Endo R, Iwamaru Y, Shimizu Y, Imamura M, Masujin K, Yamamoto T, Hattori S, Itohara S, Irie S, Yokoyama T. Tracing conformational transition of abnormal prion proteins during interspecies transmission by using novel antibodies. J Biol Chem.  285(16):11931-6 (2010)

Shimizu Y, Kaku-Ushiki Y, Iwamaru Y, Muramoto T, Kitamoto T, Yokoyama T, Mohri S, Tagawa Y. A novel anti-prion protein monoclonal antibody and its single-chain fragment variable derivative with ability to inhibit abnormal prion protein accumulation in cultured cells. Microbiol Immunol. 54(2):112-21 (2010)

Hosseinkhani H, Hosseinkhani M, Hattori S, Matsuoka R, Kawaguchi N. Micro and nano-scale in vitro 3D culture system for cardiac stem cells. J Biomed Mater Res A. 2010 94(1):1-8. (2010)

Yonezawa T, Hattori S, Inagaki J, Kurosaki M, Takigawa T, Hirohata S, Miyoshi T, Ninomiya Y. Type IV collagen induces expression of thrombospondin-1 that is mediated by integrin alpha1beta1 in astrocytes. Glia. 58,755-767 (2010)

Fujita K, Teramura N, Hattori S, Irie S, Mitsunaga-Nakatsubo K, Akimoto Y, Sakamoto N, Yamamoto T, Akasaka K. Mammalian arylsulfatase A functions as a novel component of the extracellular matrix. Connect Tissue Res. 51,388-396 (2010)

Li S, Shimono C, Norioka N, Nakano I, Okubo T, Yagi Y, Hayashi M, Sato Y, Fujisaki H, Hattori S, Sugiura N, Kimata K, Sekiguchi K. Activin a binds to perlecan through its pro-region that has heparin/heparan sulfate-binding activity. J Biol Chem.  285, 36645-55.(2010)

T. Ueno, K. Kaneko, H. Katano, Y. Sato, R. Mazitschek, K. Tanaka, S. Hattori, S. Irie, T. Sata, K. Ogawa-Goto. Expansion of the trans-Golgi network following activated collagen secretion is supported by a coiled-coil microtubule-bundling protein, p180, on the ER. Exp Cell Res. 316(3): 329-340 (2010)


K. Tanaka, T. Ebihara, M. Kusubata, E. Adachi, M. Arai, N. Kawaguchi, J. Utsunomiya, Y. Miki, M. Hiramoto, S. Hattori, S. Irie. Abnormal collagen deposition in fibromas from patient with juvenile hyaline fibromatosis. J Dermatol Sci. 55(3): 197-200 (2009)

Ueno T, Ogawa-Goto K. Use of a GFP-PML-expressing cell line as a biosensor for human cytomegalovirus infection. Methods Mol Biol. 515: 33-44 (2009)


Iwamaru Y, Shimizu Y, Imamura M, Murayama Y, Endo R, Tagawa Y, Ushiki- Kaku Y, Takenouchi T, Kitani H, Mohri S, Yokoyama T, Okada H. Lactoferrin induces cell surface retention of prion protein and inhibits prion accumulation. J Neurochem. 2008 Nov;107(3):636-46.

Fujisaki H., Adachi, E and Hattori S. Keratinocyte differentiation and proliferation are regulated by adhesion to the three-dimensional meshwork structure of type IV collagen. Connective Tissue Research  49, 426-436 (2008)

Yamamoto T, Ushiki Y, Hara S, Hall, W.W, Tsukagoshi-Nagai, H, Yokoyama ,T. Tagawa,Y., Sata, T., Yamakawa,Y., Kinoshita, N., Hattori S., and Irie S. An advantageous method utilizing new homogenizing device BioMasher and a sensitive ELISA to detect bovine spongiform encephalopathy accurately from brain tissue. J Virol. Methods. 149.316-325 (2008)


Kitamori, K., Kobayashi, M., Akamatsu, H., Hirota-Sakashita, A., Kusubata, M., Irie,S., Koyama, Y. Weakness of intercellular association of keratinocytes in severely brittle nails. ArchivesHistology and Cytology69(5) p.323-328 (2007)

Fujisaki, H., Ebihara, T., Irie,S., Kobayashi, T., Adachi, E., Mochitate, K., Hattori,S. . Keratinocyte apoptosis on type I collagen fibrils is prevented by Erk1/2 activation under high calcium condition.Connective Tissue Research(in press)

Sano, K., Asanuma-Date, K., Arisaka, F., Hattori, S., Ogawa ,H. Changes in glcosylation in vitronectin modulate multimerization and collagen binding during liver regeneration..Glycobiology. (in press)

Iijima K, Fujimoto D, Irie S. Amount of N(omega)-(Carboxymethyl)arginine generated in collagen and bovine serum albumin during glycation reactions is significantly different. Connect Tissue Res. 48(5): 271-276 (2007)

Ogawa-Goto K, Tanaka K, Ueno T, Kurata T, Sata T, Irie S. "p180 is involved in the interaction between the endoplasmic reticulum and microtubules through a novel microtubule-binding and bundling domain. Mol Biol Cell. 18(10): 3741-3751 (2007)


Matsuda, N., Koyama, Y., Hosaka, Y., Ueda, H., Watanabe, T., Araya, T., Irie, S., Takehana, K.Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis. J. Nutr. Sci. Vitaminol. 52, 211-215 (2006)

Ueno T, Eizuru Y, Katano H, Kurata T, Sata T, Irie S, Ogawa-Goto K.Novel real-time monitoring system for human cytomegalovirus-infected cells in vitro that uses a green fluorescent protein-PML-expressing cell line.Antimicrob Agents Chemother. 50(8) 2806-13 (2006)

Ino T., Hattori, M., Yoshida, T., Hattori, S., Yoshimura, K. and Takahashi, K. Improved physical and biochemical features of a collagen membrane by conjugating with soluble egg shell membrane protein. Biosci. Biotechnol. Biochem, 70, 865-873 (2006)


Hayashi, HK., Yokoyama, T., Takata, M., Iwamaru, Y., Imamura, M., Ushiki, YK. and Shinagawa, M. The N-terminal cleavage site of PrPSc from BSE differs from that of PrPSc from scrapie. Biochem. Biophys. Res. Commun. 328 1024-1027 (2005)

Miura-Yokota, Y., Matsubara, Y., Ebihara, T., Koyama, Y., Ogawa-Goto, K., Isobe, N., Hattori, S. and Irie, S. Cloning and nucleotide sequence of a novel 28-kDa protein from the mantle muscle of the squid Todarodes pacificus with homology to tropomyosin. Comp. Biochem. Physiol. B 141, 3-12 (2005)

Minaguchi, J., Koyama, Y., Meguri, N., Hosaka, Y., Ueda, H., Kusubata, M., Hirota, A., Irie, S., Mafune, N., Takehana, K. Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in Achilles tendon.J. Nutr. Sci. Vitaminol. 51 169-174 (2005)


Kajimura, D., Takahashi, S., Yoshikawa, K., Hattori, S., Sado, Y., Imamura, Y. and Hayashi, T. Non-helical type IV collagen polypeptides in human placenta. Biochem. Biophys. Res. Commu. 314, 11-16 (2004)

Hayashi H, Iwamaru Y, Takata M, Ushiki Y, Imamura M, Yokoyama T, Shinagawa M. Effect of tissue deterioration on postmortem BSE diagnosis by Immunobiochemical detection of an abnormal isoform of prion protein. J. Vet. Med. Sci. 66,515-520 (2004)

Miura-Yokota, Y., Matsubara, Y., Ebihara T., Hattori, S. and Irie, S. A Cysteine-Activated Protease Isolated from Todarodes Pacificus Squid Degrades Collagen Below its Denaturation Temperature. Connective Tissue Research 45 109-121 (2004)

Hirano, S., Yonezawa, T., Hasegawa, H., Hattori, S., Greenhill, NS., Davis, PF., Sage, EH. and Ninomiya, Y.Astrocytes express type VIII collagen during the repair process of brain cold injury. Biochem. Biophys. Res. Commun. 317 437-443 (2004)

Mimura, T., Yamagami, S., Yokoo, S., Usui, T., Tanaka, K., Hattori, S., Irie, S., Miyata, K.Araie, M., and Amano, S.Cultured Human Corneal Endothelial Cell Transplantation with a Collagen Sheet in a Rabbit Model. Investigative Ophthalmology and Visual Science 45 2992-2997 (2004)

Suzuki, Y., Hattori, S. and Isemura, M.Epigallocatechin-3-O-gallate Inhibits Fibroblast Contraction of Floating Collagen Gel: Interaction between Epigallocatechin-3-O-gallate and Platelet Derived Growth Factor. Biosci. Biotechnol. Biochem. 68 1817-1820 (2004)

Sato, K., Hattori, S., Irie, S., Sorimachi, H., Inomata. M. and Kawashima, S.Degradationoffodrinbym-calpaininfibroblastsadheringtofibrillarcollagen I gel. J. Biochem. 136 777-785 (2004)


Hirota, A., Ebihara, T., Kusubata, M., Kobayashi, M., Kobayashi, K., Kuwaba, K., Tanaka, K., Kiriyama, T., Irie, S., and Koyama, Y. Collagen of chronically inflamed skin is over-modified and upregulates secretion of matrix metalloproteinase 2 and matrix-degrqading enzymes by endothelial cells and fibroblasts. J Invest Dermatol 121:1317-1325 (2003)

Ogawa-Goto K, Tanaka K, Gibson W, Moriisihi E, Miura Y, Kurata T, Irie S and Sata T. Microtubule network facilitates nuclear targeting of human cytomegalovirus capsid. J.Virol.77: 8541-8547 (2003)

Kobayashi, T., Hattori, S. and Shinkai H. Matrix Metalloproteinases-2 and -9 are Secreted from Human Fibroblasts. Acta Dermato-Venereologica 83,105-107 (2003)

Sato, K., Hattori,S., Irie, S., and Kawashima, S. Spike formation by fibroblasts adhering to fibrillar collagen I gel. Cell Struc. Func. 28, 229-241 (2003)


Hattori,S., Fujisaki,H., Kiriyama, T., Yokoyama, T., and Irie, S. Real-time zymography and reverse zymography- A method for detecting activities of matrix metalloproteinases and their inhibitors using FITC-labeled collagen and casein as substrates. Anal. Biochm. 301, 27-34 (2002)

Ogawa-Goto,K, Irie S, Omori A, Miura Y, Katano H, Hasegawa H, Kurata T, Sata T, Arao Y. An Endoplasmic Reticulum Protein, p180, Is Highly Expressed in Human Cytomegalovirus-Permissive Cells and Interacts with the Tegument Protein Encoded by UL48. J. Virol. 76, 2350-2362 (2002)

Sugaya, M., Nakamura, K., Watanabe, T., Asashima, A., Yasaka, N., Koyama, Y., Kusubata, M., Ushiki, Y., Kimura, K., Morooka, A., Irie, S., Yokoyama, T., Inoue, K., Itohara, S., Tamaki, K. Expression of cellular prion-related protein by murine langerhans cells and keratinocytes. J. Dermatol. Sci. 28, 126-134 (2002)

Watanabe, K., and Hattori, S. Real-Time Dual Zymographic Analysis of Matrix Metalloproteinases Using FITC-Labeled Gelatin and Texas Red-Labeled Casein. Anal.Biochem. 307,390-392 (2002)

Hazeki N, Tsukamoto T, Yazawa I, Koyama M, Hattori S, Someki I, Iwatsubo T, Nakamura K, Goto J, and Kanazawa I. Ultrastructure of nuclear aggregates formed by expressing an expanded polyglutamine. Biochem Biophys Res Commun. 294, 429-440 (2002)

Hori, H., and Hattori, S., Inouye, S., Kimura, A., Irie, S., Miyazawa, H. and Sakaguchi, M. Analysis of major epitope of a2 chain of bovine type I collagen in children with bovine gelatin allergy. J. Allergy Clin. Immunol. 110,652-(2002)

Fujisaki, H. and Hattori, S. Keratinocyte apoptosis on Type I collagen gel caused by lack of laminin 5 /10/11 deposition and Akt signalling. Exp. Cell Res. 280, 255-269 (2002)

Kuwaba, K., Kobayashi, M., Nomura,,Y., Irie, S., and Koyama, Y. Size control of decorin dermatan sulfate during remodeling of collagen fibrils. in healing skin. J. Dermatol.Sci. 185-194 (2002)


Kajihara,T.,K., Hattori,S., and Irie,S. Type V collagen distribution in liver is reconstructed in coculture system of hepatocytes and stellate cells; possible function of type V collagen in liver under normal and pathological conditions. Cell Struc Func. 26 (5), 227-240 (2001)

Kobayashi,T., Nishikawa,T., Hattori,S., Yoshida,N.,Takagi,T., Watanabe, H., Hori, H.,Nagai,Y. Systematic Separation and Purification of Elastase, Gelatinase (Matrix Metalloproteinase 9), and Collagenase (Matrix Metalloproteinase 8) from Polymorphonuclear Leukocytes in Dialyzers Previously Used by Patients with Renal Failure. Protein Expression and Purification 22 , 45-51 (2001)

Kuwaba, K., Kobayashi, M., Nomura, Y., Irie, S., and Koyama, Y. Elongated dermatan sulfate in post-inflammatory healing skin distributes among collagen fibrils separated by enlarged interfibrillar gaps. Biochem, J. 358, 157-163 (2001)

Odani, H., Iijima, K., Nakata, M., Miyata, S., Kusunoki, H., Yasuda, Y., Hiki, Y., Irie, S., Maeda, K. and Fujimoto, D. Identification of N(omega)-carboxymethylarginine, a new advanced glycation endproduct in serum proteins of diabetic patients: possibility of a new marker of aging and diabetes. Biochem Biophys Res Commun. 285,5,1232-1236 (2001)

Nadanaka S, Sato C, Kitajima K, Katagiri K, Irie S, Yamagata T. Occurrence of oligosialic acids on integrin alpha 5 subunit and their involvement in cell adhesion to fibronectin. J Biol Chem. 276, 33657-33664 (2001)

Katano H, Ogawa-Goto K, Hasegawa H, Kurata T, Sata T. Human-herpesvirus-8-encoded K8 protein colocalizes with the promyelocytic leukemia protein (PML) bodies and recruits p53 to the PML bodies. Virology. 286, 446-455 (2001)

Yokoyama T, Kimura KM, Ushiki Y, Yamada S, Morooka A, Nakashiba T, Sassa T, Itohara S. In vivo conversion of cellular prion protein to pathogenic isoforms, as monitored by conformation-specific antibodies. J Biol Chem. 276, 11265-71. (2001)

Hyuga, S., Kawasaki, N., Ohta, M., Shibayama, R., Kawanishi, T., Yamagata, S., Yamagata, T., and Hayakawa, T. Ganglioside GD1a inhibits the HGF/SF-induced motility and scattering of cancer cells through suppression of tyrosine-phosphorylation of c-Met. International J. Cancer 94, 328-334 (2001)

Koyama Y, Hirota A, Mori H, Takahara H, Kuwaba K, Kusubata M, Matsubara Y, Kasugai S, Itoh M, Irie S. Ingestion of gelatin has differential effect on bone mineral density and body weight in protein undernutrition. J Nutr Sci Vitaminol (Tokyo). 47, 84-86. 2001

Tsuji-Yamada, J., Nakazawa, M., Takahashi, K., Iijima, K., Hattori, S., Okuda, K., 67) Minami, M., Ikezawa, Z., Sasaki, T. Effect of IL-12 Encoding Plasmid Administration on Tight-Skin Mouse. Biochem Biophys Res Commun 280, 707-712 (2001)


K.Katagiri, M. Hattori, N. Minato, S. Irie, K. Takatsu and T. Kinashi. Rap1 is a potent activation signal for LFA-1 distinct from PKC and PI3-kinase. Mol. Cell. Biol. 20, 1956-1969 (2000)

Watanabe, K., Takahashi, H., Habu, Y., Kamiya-Kubushiro, N., Kamiya, S., Nakamura, H., Yajima, H., Ishii, T., Katayama, T., Miyazaki, K., Fukai, F. Interaction with heparin and matrix metalloproteinase 2 cleavage expose acryptic anti-adhesive site of fibronectin. Biochemistry 39, 7138-44 (2000)

Sato, K., Ebihara, T., Adachi, E.,Kawashima, S., Hattori, S. and Irie, I. The reconstituted type I collagen fibrils from skins of variously aged bovines exert different effects on the morphology and integrin ?2?1 expression of fibroblasts in culture Connective Tissue 32, 1-10 (2000)

Sato, K., Ebihara, T., Adachi, E.,Kawashima, S., Hattori, S. and Irie, I. Possible involvment of aminotelopeptide in self-assembly and thermal stability of collagen I as revealed by its removal with proteases J. Biol. Chem. 275, 25870-25875 (2000)

Kobayashi, T., Hattori, S., Nagai, Y. and Tajima, S. Differential regulation of the secretions of matrix metalloproteinase (MMP)-9 and tissue inhibitor of metalloproreinases (TIMP)-1 from human keratinocyte in culture. IUBMB Life 50, 221-226 (2000)

Ueoka, C., Kaneda, N., Okazaki, I., Nadanaka, S., Muramatsu, T., and Sugahara, K. Neuronal Cell Adhesion, Mediated by the Heparin-binding Neuroregulatory Factor, Midkine, Is Specifically inhibited by Chondroitin Sulfate E. Structural and Functional Implications of the Oversulfated Chondroitin Sulfate, J. Biol. Chem. 275, 37407-37413. (2000)

Sakaguchi, M., Toda, M., Ebihara, T., Irie, S., Hori, H., Imai, A., Yanagida, M., Miyazawa, H., Ohsuna, H., Ikezawa,.Z., Inouye, S. IgE antibody to fish gelatin (type I collagen) in patients with fish allergy. Journal of Allergy and Clinical Immunology, 106, 579-584, (2000)

Ijima K, Murata M, Takahara H, Irie S, Fujimoto D. Identification of N(omega)-carboxymethylarginine as a novel acid-labileadvanced glycation end product in collagen. Biochem J. 347 Pt 1: 23-27 (2000)

Koyama Y, Norose-Toyoda K, Hirano S, Kobayashi M, Ebihara T, Someki I, Fujisaki H, Irie S. Type I collagen is a non-adhesive extracellular matrix for macrophages. Arch Histol Cytol. 63(1): 71-79 (2000)


Yajima, H., Watanabe, K., Takemura, T. and Ishii, T. Inhibitory Effect of the Conformation of Amylose as a Function of I2Concentration on Glucoamylase Activity. Biosci. Biotechnol. Biochem. 63, 1011-1016 (1999)

Kuwaba, K., Nomura, Y., Irie, S., and Koyama, Y.  Temporal changes in disaccharide composition of dermatan sulfate in the skin after epicutaneous application of hapten. J. Dermatol. Sci. 19, 23-30 (1999)

Watanabe, K. and Koyama, Y. Adhesion of macrophages on collagen irradiated with ultraviolet light. J. Biomater. Sci. Polym. Edn. 10, 351-362 (1999)

Sakaguchi, M., Hori, H., Ebihara, T., Irie,S., Yanagida, M., and Inouye, S. Response of IgE in bovine gelatin-sensitive children to gelatins from various animal. Immunology 96, 286-290 (1999)

Yoneda, C., Hirayama, Y., Nakaya, M., Matsubara, Y., Irie, S., Hatae, K. and Watabe, S. The occurrence of two types of collagen proα-chain in the abalone Haliotis discus muscle Eur. J. Biochem. 261, 714-721 (1999)

Nadanaka, S., Kitagawa, H., Goto, F., Tamura, J., Neumann, K.W., Ogawa, T.,and 45) Sugahara, K. Involvement of the core protein in the first b-N-acetylgalactosamine transfer to the glycosaminoglycan-protein linkage-region tetrasaccharide and in the subsequent polymerization: the critical determining step for chondroitin sulphate biosynthesis. Biochem. J. 340, 353-357 (1999)

Nadanaka, S., Fujita, M.,and Sugahara, K. Demonstration of a novel sulfotransferase in fetal bovine serum, which transfers sulfate to the C6 position of the GalNAc residue in the sequence iduronic acid a1-3GalNAcb1-4iduronic acid in dermatan sulfate. FEBS Lett. 452, 185-189 (1999)

Ueoka, C., Nadanaka, S., Seno, N., Khoo, K.H.,and Sugahara, K. Structural determination of novel tetra- and hexasaccharide sequences isolated from chondroitin sulfate H (oversulfated dermatan sulfate) of hagfish notochord. Glycoconj. J. 16, 291-305 (1999)

Kuwaba, K., Nomura, Y., Irie, S., and Koyama, Y. Temporal changes in disaccharide composition of dermatan sulfate in the skin after epicutaneous application of hapten. J. Dermatol. Sci. 19, 23-30 (1999)

Kusubata, M., Hirota, A., Ebihara, T., Kuwaba, K., Matsubara, Y. Sasaki, T.,Kusakabe, M., Tsukada, T., Irie, S., and Koyama, Y. Spatiotemporal changes of fibronectin, tenascin-C, fibulin-1, and fibulin-2 in the skin during the development of chronic contact dermatitis. J. Invest. Dermatol. 113, 906-912 (1999)

Salgado, C.G., Nakamura, K., Sugaya, M., Tada, Y., Asahina, A., Koyama, Y., Irie, S., and Tamaki, K. Functional CD40 ligand is expressed onepidermal Langerhans cells. J. Leukoc. Biol. 66, 281-285 (1999)

Salgado, C.G., Nakamura, K., Sugaya, M., Tada, Y., Asahina, A., Fukuda, S., Koyama, Y. ,Irie, S., and Tamaki, K. Differential effects ofcytokines and immunosuppressive drugs on CD40, B7-1, and B7-2 expression onpufiried epidermal Langerhans cells. J. Invest. Dermatol. 113, 1021-1027 (1999)

Hattori, S., Adachi, E., Ebihara, T., Shirai, T., Someki, I. and Irie, S. Alkali-treated collagen retained the triple helical conformation and the ligand activity for cell adhesion via a2b1 integrin. J. Biochem.125, 676-684 (1999)

Suzuki, Y., Someki, I., Adachi, E., Irie, S. and Hattori, S. Interaction of collagen molecules from the aspect of fibril formation; acid-soluble, alkali-treated and MMP1-digested fragments of Type I Collagen. J.Biochem. 126, 54-67 (1999)

Yajima, H., Watanabe, K., Takemura, T. and Ishii, T. Inhibitory effect of the conformation of amylose as a function of I2 concentration on the glucoamylase activity. Biosci. Biotechnol. Biochem. 63, 1011-1016 (1999)

Fujisaki, H. and Hattori, S. Gelatin-binding immunoglobulins from normal bovine serum. Connective Tissue 31, 155-160 (1999)

Sakaguchi, M., Hori, H., Hattori, S., Irie, S., Imai, A., Yanagida, M., Miyazawa, H., Toda., M., and Inoue, S. IgE reactivity to a1and a2 chains of denatured bovine type I collagen in children with bovine gelatine allergy. J Allergy Clin Immunol 104, 695-699 (1999)

Miura, Y., Arai, T., Ohtake, A., Ito, M., Yamamoto, K., and Yamagata, T. Requirement for a different hydrophobic moiety and reliable chromogenic substrate for endo-type glycosylceramidases. Glycobiology, 9, 957-960 (1999)

Nagaya, N., Yamagata, T., Yamagata, S., Iyoda, K., Ito, H.,Hasegawa, Y., and Iwata, H. Examination of synovial fluid and serum hyaluronidase activity as a joint marker in rheumatoid arthritis and osteoarthritis patients (by zymography). Ann. Rheum. Dis., 58, 186-188 (1999)

Hyuga, S., Yamagata, S., Takatsu, Y., Hyuga, M., Nakanishi, H., Furukawa, K. and Yamagata, T., Suppression of FBJ-LL cell adhesion to vitronectin by ganglioside GD1a and loss of metastatic capacity. International J. Cancer, 83, 685-691 (1999)

Hirayama, N., Miura, Y., Iijima, K., Ohya, K., Irie, S., and Fujimoto, D. Increased Urinary excretion of pyridinium crosslinks in streptozotocin-induced diabetic rats. Biomedical Res. 20, 133-140 (1999)

Katagiri K, Yokosawa H, Kinashi T, Kawashima S, Irie S, Tanaka K, Katagiri T. Ubiquitin-proteasome system is involved in induction of LFA-1/ICAM-1-dependent adhesion of HL-60 cells. J Leukoc Biol. 65(6): 778-785 (1999)

Sato K, Katagiri K, Hattori S, Tsuji T, Irimura T, Irie S, Katagiri T. Laminin 5 promotes activation and apoptosis of the T cells expressing alpha3beta1 integrin. Exp Cell Res. 247(2): 451-460 (1999)


Shirai, T., Hattori, S., Sakaguchi, M., Inouye, S., Kimura, A., Ebihara, T., Irie, S., Nagai, Y. and Hori, H. The complete cDNA coding sequence for the bovine proa2(I) chain of type I procollagen. Matrix Biol. 17, 85-88 (1998)

Koyama, Y., Kusubata, M., Yoshiki, A., Hiraiwa, N., Ohashi, N., Irie, S., and Kusakabe, M.Effect of tenascin-C deficiency on chemically induced dermatitis in the mouse. J. Invest. Dermatol. 11, 930-935 (1998)

Ogawa-Goto, K. , Arao, Y., Ito, Y., Ogawa, T., Abe, T., Kurata, T. , Irie, S.and Akanuma, H. Specific binding of human cytomegalovirus to sulfated glucuronyl glycosphingolipids and their inhibitory effects on the infection. J.Gen.Virol. 79, 2533-2541 (1998)

Kobayashi, T., Hattori, S., Nagai, Y., Tajima, S. and Nishikawa, T. Differential regulation of MMP-2 and MMP-9 gelatinase in cultured human keratinocytes. Dermatology 197, 1-5 (1998)

Nakajima, H., Miura, Y., and Yamagata, T. Glycosylation of amphipathic lactoside primers with consequent inhibition of endogenous glysosphingolipid synthesis. J. Biochem., 124, 148-156 (1998)

Ji, L., Ito, M., Zhang, G., Hirabayashi, Y., Inokuchi, J., and Yamagata , T. Effects of endoglycoceramidase or D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol on glucose uptake, glycolysis, and mitochondrial respiration in HL60 cells. Arch Biochem. Biophys., 359, 107-114 (1998)

Ogawa-Goto K, Abe T. Gangliosides and glycosphingolipids of peripheral nervous system myelins--a minireview. Neurochem Res. 23(3): 305-310 (1998)


Kobayashi, T., Hattori, S., Nagai, Y., Sakuraoka, K., and Nishikawa, T. Secration of different types of gelatinase from cultured human keratinocytes. J. Dermatology 24, 213-216 (1997)

Kobayashi, T., Konohara, A. and Hattori, S. A case of liner IgA disease: an immunofluorescent study using confocal scan microscopy. J. Dermatology 24, 306-309 (1997)

Watanabe, K., Nakagawa, J., Ebihara, T. and Okamoto, Y. Effects of the methylene chain length of chemically introduced crosslinks on the properties of collagen. Polymer 38, 286-289 (1997)

Watanabe, K. Comparison of properties of the collagen cross-linked with aliphatic or aromatic reagent Polym. J. 29, 286-289 (1997)

Watanabe, K., Tezuka, Y. and Ishii, T. Configuration between re-formed collagen triple helices and artificially introduced cross-links in gelatin gels. Macromolecules 30, 7910-7913 (1997)

Watanabe, K., Muto, K. and Ishii, T. Conformational analysis of poly(L-tyrosine) and tyrosyl oligomers based on backbone circular dichroism spectra obtained by fluorescence-detected circular dichroism. Biospectroscopy 3, 103-111 (1997)


Sasaki,T., Hori,H., Arai, K., Hattori, S. and Nagai, Y. Effect of a factor derived from polymorphonuclear leukocytes on the growth and collagen metabolism in normal and screroderma skin fibrolast cultures. J. Dermatological Science 11, 10-18 (1996)

Hattori, S., Sakai, K., Watanabe, K. and Fujii, T. The induction of metachromasia and ciircular dichroism of Coomassie Brilliant Blue R-250 with collagn and histone H1 is due to the low content of hydrophobic amino acid content of these proteins. J. Biochem. 119, 400-408 (1996)

Kobayashi, T., Onoda, N., Takagi, T., Hori, H., Hattori, S., Nagai, Y., Tajima, S., and Nishikawa, T. Immunolocalizations of human gelatinase (type IV collagenase, MMP-9) and TIMP (tissue inhibitor of metalloproteinases) in the normal epidermis and some epidermal tumors. Arch Dermatol. Res. 288, 239-244 (1996)

Kobayashi, T., Sakuraoka, K., Hattori, S., Hori, H., Nagai, Y., Tajima, S. and Nishikawa, T. Immunolocalization of human gelatinase (type IV collagenase, MMP 9) and tissue inhibitor of metalloproteinase 1 in Hailey-Hailey and Darier's Diseases. Dermatology 193, 110-114 (1996)

Mizuta, T., Shimada, H., Arai, K., Hori, H., Hattori, S., Yamamoto, K., Sakai, T., and Nagai, Y. Characterization of monoclonal antibodies recognizing human merosin and their use in affinity purification of native merosin. Hybridoma 15, 373-378 (1996)

Hattori, S. and Fujisaki, H. Double immunodetection of proteins transfered onto a membrane using two different chemiluminescent reagent. Anal. Biochem. 243, 277-279 (1996)

Sakai, K., Fujii, T., and Hayashi, T. Comformational change precedes the formation of multumeric fibronectin. J. Biochem. 119, 58-62 (1996)

Koyama, Y., Norose, K., Kusubata, M., Irie, S., and Kusakabe, M. Differential expression of tanascin in the skin during hapten-induced dermatitis. Histochem. Cell Biol. 106, 263-273 (1996)

Koyama, Y., and Marunouchi, T. Macrohage colony-stimulating factor (M-CSF) inhibits the decrease in the amount of rRNA and IAbeta mRNA in cultured epidermal langerhans cells of the mouse. J. Dermatol. 23, 73-82 (1996)

Kuwaba, K., and Fujii T. Identification of type III colalgen -derived polymeric components in commercial line-processed hede gelatin. J. Photogr. Sci. 44, 62-65 (1996)

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Watanabe, K., Nakagawa, J., Ebihara., and Okamoto, Y. Structural effects of cross-linked colalgen. Polymer 37, 1285-1288 (1996)

Katagiri K, Kinashi T, Irie S, Katagiri T. Differential regulation of leukocyte function-associated antigen-1/ intercellular adhesion molecules-1-dependent adhesion and aggregation in HL-60 cells. Blood. 87(10): 4276-4285 (1996)

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