Ueshima S, Yasumoto M, Kitagawa Y, Akazawa K, Takita T, Tanaka K, Hattori S, Mizutani K, Mikami B, Yasukawa K. Insights into the catalytic mechanism of Grimontia hollisae collagenase through structural and mutational analyses. FEBS Lett. 597, 2473-2483 (2023) PMID: 37698340

Tani H, Kobayashi E, Yagi S, Tanaka K, Kameda-Haga K, Shibata S, Moritoki N, Takatsuna K, Moriwaki T, Sekine O, Umei TC, Morita Y, Soma Y, Kishino Y, Kanazawa H, Fujita J, Hattori S, Fukuda K, Tohyama S. Heart-derived collagen promotes maturation of engineered heart tissue. Biomaterials. 299, 122174 (2023) PMID: 37285642

Cabral WA, Stephan C, Terajima M, Thaivalappil AA, Blanchard O, Tavarez UL, Narisu N, Yan T, Wincovitch SM, Taga Y, Yamauchi M, Kozloff KM, Erdos MR, Collins FS. Bone dysplasia in Hutchinson-Gilford progeria syndrome is associated with dysregulated differentiation and function of bone cell populations. Aging Cell. e13903 (2023) PMID: 37365004

Boudko SP, Konopka EH, Kim W, Taga Y, Mizuno K, Springer TA, Hudson BG, Moy TI, Lin FY. A recombinant technique for mapping functional sites of hetero-trimeric collagen helices: collagen IV CB3 fragment as a prototype for integrin binding. J Biol Chem. 104901 (2023) PMID: 37302550

Li C, Zhu Y, Liu W, Xiang W, He S, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T. Impaired mitophagy causes mitochondrial DNA leakage and STING activation in ultraviolet B-irradiated human keratinocytes HaCaT. Arch Biochem Biophys. 737, 109553 (2023) PMID: 36842493

Wang C, Kang Y, Liu P, Liu W, Chen W, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T. Combined use of dasatinib and quercetin alleviates overtraining-induced deficits in learning and memory through eliminating senescent cells and reducing apoptotic cells in rat hippocampus. Behav Brain Res. 440, 114260 (2023) PMID: 36535433

Liu P, Wang C, Chen W, Kang Y, Liu W, Qiu Z, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T. Inhibition of GluN2B pathway is involved in the neuroprotective effect of silibinin on streptozotocin-induced Alzheimer's disease models. Phytomedicine. 109, 154594 (2023) PMID: 36610115


Ishikawa Y, Taga Y, Coste T, Tufa SF, Keene DR, Mizuno K, Tournier-Lasserve E, Gould DB. Lysyl hydroxylase 3 mediated post-translational modifications are required for proper biosynthesis of collagen α1α1α2(IV). J Biol Chem. 298, 102713 (2022) PMID: 36403858

Zhu Y, Chen S, Liu W, Xu F, Lu J, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T. IGF-1R/YAP signaling pathway is involved in collagen V-induced insulin biosynthesis and secretion in rat islet INS-1 cells. Connect Tissue Res. 63, 498-513 (2022) PMID: 35129018

Song XY, Liu PC, Liu WW, Zhou J, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T. Silibinin inhibits ethanol- or acetaldehyde-induced ferroptosis in liver cell lines. Toxicol In Vitro. 82, 105388 (2022) PMID: 35595033

Song XY, Liu PC, Liu WW, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T. Protective effects of silibinin against ethanol- or acetaldehyde-caused damage in liver cell lines involve the repression of mitochondrial fission. Toxicol In Vitro. 80, 105330 (2022) PMID: 35158046

Taniguchi Y, Kawahara K, Takashima M, Cotte M, Mazurek J, Kumazawa Y, Taga Y, Nakazawa T. Organic materials used for Giant Buddhas and Wall Paintings in Bamiyan, Afghanistan. Appl Sci. 12, 9476 (2022) DOI: 10.3390/app12199476

Terajima M, Taga Y, Nakamura T, Guo HF, Kayashima Y, Maeda-Smithies N, Parag-Sharma K, Kim JS, Amelio AL, Mizuno K, Kurie JM, Yamauchi M. Lysyl hydroxylase 2 mediated collagen post-translational modifications and functional outcomes. Sci Rep. 12, 14256 (2022) PMID: 35995931

Ikeuchi T, Yasumoto M, Takita T, Tanaka K, Kusubata M, Hayashida O, Hattori S, Mizutani K, Mikami B, Yasukawa K. Crystal structure of Grimontia hollisae collagenase provides insights into its novel substrate specificity toward collagen. J Biol Chem. 298, 102109 (2022) PMID: 35679897

Taga Y, Iwasaki Y, Tometsuka C, Funato N, Shigemura Y, Kusubata M, Mizuno K. Identification of a highly stable bioactive 3-hydroxyproline-containing tripeptide in human blood after collagen hydrolysate ingestion. NPJ Sci Food. 6, 29 (2022) PMID: 35662250

Gao Y, Kai M, Kang Y, Liu W, Liu X, Long X, Hayashi T, Hattori S, Mizuno K, Fujisaki H, Ikejima T. Type I collagen reduces lipid accumulation during adipogenesis of preadipocytes 3T3-L1 via the YAP-mTOR-autophagy axis. Biochim Biophys Acta Mol Cell Biol Lipids. 1867, 159181 (2022) PMID: 35595017

Takenokuchi M, Matsumoto K, Nitta Y, Takasugi R, Inoue Y, Iwai M, Kadoyama K, Yoshida K, Takano-Ohmuro H, Taniguchi T. In Vitro and In Vivo Antiglycation Effects of Connarus ruber Extract. Planta Med. 88, 1026-1035 (2022) PMID: 34861700

Liu WW, Wang F, Li C, Song XY, Otkur W, Zhu YY, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T. Silibinin relieves UVB-induced apoptosis of human skin cells by inhibiting the YAP-p73 pathway. Acta Pharmacol Sin. 43, 2156-2167 (2022) PMID: 34912007

Masuda K, Watanabe K, Ueno T, Nakazawa Y, Tanabe Y, Ushiki-Kaku Y, Ogawa-Goto K, Ehara Y, Saeki H, Okumura T, Nonaka K, Kamihira M. Novel cell line development strategy for monoclonal antibody manufacturing using translational enhancing technology. J Biosci Bioeng. 133, 273-280 (2022) PMID: 34930670

Fujii KK, Taga Y, Takagi YK, Masuda R, Hattori S, Koide T. The thermal stability of the collagen triple helix is tuned according to the environmental temperature. Int J Mol Sci. 23, 2040 (2022) PMID: 35216155

Saito T, Terajima M, Taga Y, Hayashi F, Oshima S, Kasamatsu A, Okubo Y, Ito C, Toshimori K, Sunohara M, Tanzawa H, Uzawa K, Yamauchi M. Decrease of lysyl hydroxylase 2 activity causes abnormal collagen molecular phenotypes, defective mineralization and compromised mechanical properties of bone. Bone. 154, 116242 (2022) PMID: 34718219


Liu X, Zu E, Chang X, Ma X, Wang Z, Song X, Li X, Yu Q, Kamei KI, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T, Wang DO. Bi-phasic effect of gelatin in myogenesis and skeletal muscle regeneration. Dis Model Mech. 14, dmm049290 (2021) PMID: 34821368

Liu X, Chen W, Wang C, Liu W, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T. Silibinin ameliorates depression/anxiety-like behaviors of Parkinson's disease mouse model and is associated with attenuated STING-IRF3-IFN-β pathway activation and neuroinflammation. Physiol Behav. 241, 113593 (2021) PMID: 34536434

Zhu Y, Chen S, Liu W, Zhang L, Xu F, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T. Collagens I and V differently regulate the proliferation and adhesion of rat islet INS-1 cells through the integrin β1/E-cadherin/β-catenin pathway. Connect Tissue Res. 62, 658-670 (2021) PMID: 33957832

Hattori S, Kiriyama-Tanaka T, Kusubata M, Taga Y, Ebihara T, Kumazawa Y, Imai K, Miura M, Mezaki Y, Tikhonov A, Senoo H. Preservation of collagen in the soft tissues of frozen mammoths. PLoS One. 16, e0258699 (2021) PMID: 34714842

Zhu Y, Liu W, Chen S, Xu F, Zhang L, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T. Collagen type I enhances cell growth and insulin biosynthesis in rat pancreatic cells. J Mol Endocrinol. 67, 135-148 (2021) PMID: 34370695

Liu X, Wang C, Liu W, Song S, Fu J, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T. Oral administration of silibinin ameliorates cognitive deficits of Parkinson's disease mouse model by restoring mitochondrial disorders in hippocampus. Neurochem Res. 46, 2317-2332 (2021) PMID: 34097239

Liu X, Liu W, Wang C, Chen Y, Liu P, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T. Silibinin attenuates motor dysfunction in a mouse model of Parkinson's disease by suppression of oxidative stress and neuroinflammation along with promotion of mitophagy. Physiol Behav. 239, 113510 (2021) PMID: 34181930

Ide K, Takahashi S, Sakai K, Taga Y, Ueno T, Dickens D, Jenkins R, Falciani F, Sasaki T, Ooi K, Kawashiri S, Mizuno K, Hattori S, Sakai T. The dipeptide prolyl-hydroxyproline promotes cellular homeostasis and lamellipodia-driven motility via active β1-integrin in adult tendon cells. J Biol Chem. 297, 100819 (2021) PMID: 34029590

Taga Y, Tanaka K, Hattori S, Mizuno K.  In-depth correlation analysis demonstrates that 4-hydroxyproline at the Yaa position of Gly-Xaa-Yaa repeats dominantly stabilizes collagen triple helix. Matrix Biol Plus. 10, 100067 (2021) PMID: 34195597

Miyamoto-Mikami E, Kumagai H, Tanisawa K, Taga Y, Hirata K, Kikuchi N, Kamiya N, Kawakami R, Midorikawa T, Kawamura T, Kakigi R, Natsume T, Zempo H, Suzuki K, Kohmura Y, Mizuno K, Torii S, Sakamoto S, Oka K, Higuchi M, Naito H, Miyamoto N, Fuku N. Female athletes genetically susceptible to fatigue fracture are resistant to muscle injury: Potential role of COL1A1 variant. Med Sci Sports Exerc. 53, 1855-1864 (2021) PMID: 33731655

Tometsuka C, Funato N, Mizuno K, Taga Y. Long-term intake of ginger protease-degraded collagen hydrolysate reduces blood lipid levels and adipocyte size in mice. Curr Res Food Sci. 4, 175-180 (2021) PMID: 33870215

Takeyari S, Kubota T, Ohata Y, Fujiwara M, Kitaoka T, Taga Y, Mizuno K, Ozono K. 4-Phenylbutyric acid enhances the mineralization of osteogenesis imperfecta iPSC-derived osteoblasts. J Biol Chem. 296, 100027 (2021) PMID: 33154166  

Liu WW, Wang F, Li C, Otkur W, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Onodera S, Ikejima T. Silibinin treatment protects human skin cells from UVB injury through upregulation of estrogen receptors. J Photochem Photobiol B. 216, 112147 (2021) PMID: 33561689

Li C, Liu WW, Wang F, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T. DNA damage-triggered activation of cGAS-STING pathway induces apoptosis in human keratinocyte HaCaT cells. Mol Immunol. 131, 180-190 (2021) PMID: 33423764

Ishikawa Y, Taga Y, Zientek K, Mizuno N, Salo AM, Semenova O, Tufa SF, Keene DR, Holden P, Mizuno K, Gould DB, Myllyharju J, Bächinger HP. Type I and type V procollagen triple helix use different subsets of the molecular ensemble for lysine post-translational modifications in the rER. J Biol Chem. 206, 100453 (2021) PMID: 33631195

Song XY, Li RH, Liu WW, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T. Effect of silibinin on ethanol- or acetaldehyde-induced damge of mouse primary hepatocytes in vitro. Toxicol In Vitro. 70, 105047 (2021) PMID: 33137447

Sano K, Saito S, Suzuki T, Kotani O, Ainai A, van Riet E, Tabata K, Saito K, Takahashi Y, Yokoyama M, Sato H, Maruno T, Usami K, Uchiyama S, Ogawa-Goto K, Hasegawa H. An influenza HA stalk reactive polymeric IgA antibody exhibits anti-viral function regulated by binary interaction between HA and the antibody. PLoS One. 16, e0245244 (2021) PMID: 33412571


Funato N, Taga Y, Laurie LE, Tometsuka C, Kusubata M, Ogawa-Goto K. The transcription factor HAND1 Is involved in cortical bone mass through the regulation of collagen expression. Int J Mol Sci. 21, 8638 (2020) PMID: 33207791

Long X, Gao Y, Liu W, Liu X, Hayashi T, Mizuno K, Hattori S, Ikejima T. Natural flavonoid silibinin promotes the migration and myogenic differentiation of murine C2C12 myoblasts via modulation of ROS generation and down-regulation of estrogen receptor α expression. Mol Cell Biochem. 474, 243-261 (2020) PMID: 32789659

Fujisaki H, Futaki S, Yamada M, Sekiguchi K, Hayashi T, Hattori S. Adhesion to type I collagen fibrous gels induces E- to N-cadherin switching without other EMT-related phenotypes in lung carcinoma cell A549. bioRxiv (2020) DOI: 10.1101/2020.10.02.323881

Hayashi K, Ikeuchi T, Morishita R, Qian J, Kojima K, Takita T, Tanaka K, Hattori S, Yasukawa K. The roles of histidine and tyrosine residues in the active site of collagenase in Grimontia hollisae. J Biochem. 168, 385-392 (2020) PMID: 32386303

Taga Y, Kusubata M, Mizuno K. Quantitative analysis of the positional distribution of hydroxyproline in collagenous Gly-Xaa-Yaa sequences by LC-MS with partial acid hydrolysis and precolumn derivatization. Anal Chem. 92, 8427-8434 (2020) PMID: 32437599

Iwasaki Y, Taga Y, Suzuki A, Kurokawa M, Sato Y, Shigemura Y. Effect of co-ingestion of collagen peptides with yogurt on blood absorption of short chain hydroxyproline peptides. Appl Sci. 10, 4066 (2020) DOI: 10.3390/app10124066

Si L, Fu J, Liu WW, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Onodera S, Ikejima T. Silibinin-induced mitochondria fission leads to mitophagy, which attenuates silibinin-induced apoptosis in MCF-7 and MDA-MB-231 cells. Arch Biochem Biophys. 685, 108284 (2020) PMID: 32014401

Yamada T, Takechi M, Yokoyama N, Hiraoka Y, Ishikubo H, Usami T, Furutera T, Taga Y, Hirate Y, Kanai-Azuma M, Yoda Y, Ogawa-Goto K, Iseki S. Heterozygous mutation of the splicing factor Sf3b4 affects development of the axial skeleton and forebrain in mouse. Dev Dyn. 249, 622-635 (2020) PMID: 31900962

Nogimura D, Mizushige T, Taga Y, Nagai A, Shoji S, Azuma N, Kusubata M, Adachi S, Yoshizawa F, Kabuyama Y. Prolyl-hydroxyproline, a collagen-derived dipeptide, enhances hippocampal cell proliferation, which leads to antidepressant-like effects in mice. FASEB J. 34, 5715-5723 (2020) PMID: 32115749

Tanaka K, Okitsu T, Teramura N, Iijima K, Hayashida O, Teramae H, Hattori S. Recombinant collagenase from Grimontia hollisae as a tissue dissociation enzyme for isolating primary cells. Sci Rep. 10, 3927 (2020) PMID: 32127566

Fujimaki H, Uchida K, Inoue G, Matsushita O, Nemoto N, Miyagi M, Inage K, Takano S, Orita S, Ohtori S, Tanaka K, Sekiguchi H, Takaso M. Polyglycolic acid-collagen tube combined with collagen-binding basic fibroblast growth factor accelerates gait recovery in a rat sciatic nerve critical-size defect model. J Biomed Mater Res B Appl Biomater. 108, 326-332 (2020) PMID: 31016841

Liu X, Long X, Gao Y, Liu W, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ogura T, Onodera S, Wang DO, Ikejima T. Type I collagen inhibits adipogenic differentiation via YAP activation in vitro. J Cell Physiol. 235, 1821-1837 (2020) PMID: 31432516

Liu X, Gao Y, Long X, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ogura T, Wang DO, Ikejima T. Type I collagen promotes the migration and myogenic differentiation of C2C12 myoblasts via the release of interleukin-6 mediated by FAK/NF-κB p65 activation. Food Funct. 11, 328-338 (2020) PMID: 31799535

Si L, Fu J, Liu W, Hayashi T, Nie Y, Mizuno K, Hattori S, Fujisaki H, Onodera S, Ikejima T. Silibinin inhibits migration and invasion of breast cancer MDA-MB-231 cells through induction of mitochondrial fusion. Mol Cell Biochem. 463, 189-201 (2020) PMID: 31612353

Liu P, Cui L, Liu B, Liu W, Hayashi T, Mizuno K, Hattori S, Ushiki-Kaku Y, Onodera S, Ikejima T. Silibinin ameliorates STZ-induced impairment of memory and learning by up- regulating insulin signaling pathway and attenuating apoptosis. Physiol Behav. 213, 112689 (2020) PMID: 31669775


Terajima M, Taga Y, Sricholpech M, Kayashima Y, Sumida N, Maeda N, Hattori S, Yamauchi M. Role of glycosyltransferase 25 domain 1 in type I collagen glycosylation and molecular phenotypes. Biochemistry. 58, 5040-5051 (2019) PubMed PMID: 31726007

Fujii KK, Taga Y, Sakai T, Ito S, Hattori S, Nagata K, Koide T. Lowering the culture temperature corrects collagen abnormalities caused by HSP47 gene knockout. Sci Rep. 9, 17433 (2019) PubMed PMID: 31758055

Zhang X, Chen YR, Zhao YL, Liu WW, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ogura T, Onodera S, Ikejima T. Type I collagen or gelatin stimulates mouse peritoneal macrophages to aggregate and produce pro-inflammatory molecules through upregulated ROS levels. Int Immunopharmacol. 76, 105845 (2019) PubMed PMID: 31470266

Kinoshita S, Mera K, Ichikawa H, Shimasaki S, Nagai M, Taga Y, Iijima K, Hattori S, Fujiwara Y, Shirakawa JI, Nagai R. N(omega) -(carboxymethyl)arginine is one of the dominant advanced glycation end products in glycated collagens and mouse tissues. Oxid Med Cell Longev. 9073451 (2019) PubMed PMID: 31583049

Yamauchi M, Taga Y, Terajima M. Analyses of lysine aldehyde cross-linking in collagen reveal that the mature cross-link histidinohydroxylysinonorleucine is an artifact. J Biol Chem. 294, 14163 (2019) PubMed PMID: 31541027

Yang J, Sun Y, Liu X, Xu F, Liu W, Hayashi T, Imamura Y, Mizuno K, Hattori S, Tanaka K, Fujisaki H, Tashiro SI, Onodera S, Ikejima T. Silibinin's regulation of proliferation and collagen gene expressions of rat pancreatic beta-cells cultured on types I and V collagen involves beta-catenin nuclear translocation. Connect Tissue Res. 60, 463-476 (2019) PubMed PMID: 30871385

Si L, Liu W, Hayashi T, Ji Y, Fu J, Nie Y, Mizuno K, Hattori S, Onodera S, Ikejima T. Silibinin-induced apoptosis of breast cancer cells involves mitochondrial impairment. Arch Biochem Biophys. 671, 42-51 (2019) PubMed PMID: 31085166

Zhao YL, Zhang X, Liu WW, Yang YT, Gao ZK, Liu XL, Liu W, Hayashi T, Yamato M, Fujisaki H, Hattori S, Mizuno K, Atsuzawa Y, Tashiro SI, Onodera S, Ikejima T. Reactive oxygen species are responsible for the cell aggregation and production of pro-inflammatory mediators in phorbol ester (PMA)-treated U937 cells on gelatin-coated dishes through upregulation of autophagy. Connect Tissue Res. 60, 323-334 (2019) PubMed PMID: 30277081

Mizushige T, Nogimura D, Nagai A, Mitsuhashi H, Taga Y, Kusubata M, Hattori S, Kabuyama Y. Ginger-degraded collagen hydrolysate exhibits antidepressant activity in mice. J Nutr Sci Vitaminol (Tokyo). 65, 251-257 (2019) PubMed PMID: 31257265

Terajima M, Taga Y, Cabral WA, Liu Y, Nagasawa M, Sumida N, Kayashima Y, Chandrasekaran P, Han L, Maeda N, Perdivara I, Hattori S, Marini JC, Yamauchi M. Cyclophilin B control of lysine post-translational modifications of skin type I collagen. PLoS Genet. 15, e1008196 (2019) PubMed PMID:31173582

Sato K, Jimi S, Kusubata M. Generation of bioactive prolyl-hydroxyproline (Pro-Hyp) by oral administration of collagen hydrolysate and degradation of endogenous collagen. Int J Food Sci Technol. 54, 1976-1980 (2019) DOI: 10.1111/ijfs.14145

Ueno T, Taga Y, Yoshimoto R, Mayeda A, Hattori S, Ogawa-Goto K. Component of splicing factor SF3b plays a key role in translational control of polyribosomes on the endoplasmic reticulum. Proc Natl Acad Sci U S A. 116, 9340-9349 (2019) PubMed PMID: 31004060

Taga Y, Iwasaki Y, Shigemura Y, Mizuno K. Improved in vivo tracking of orally administered collagen hydrolysate using stable isotope labeling and LC-MS techniques. J Agric Food Chem. 67, 4671-4678 (2019) PubMed PMID 30929424

Fujisaki H, Futaki S, Mizuno K, Hattori S. Evaluation of keratinocyte proliferation on two- and three-dimensional type I collagen substrates. J Vis Exp. (2019) DOI: 10.3791/59339

Yang J, Sun Y, Xu F, Liu W, Hayashi T, Hattori S, Ushiki-Kaku Y, Onodera S, Tashiro SI, Ikejima T. Silibinin protects rat pancreatic beta-cell through up-regulation of estrogen receptors' signaling against amylin- or Abeta1-42 -induced reactive oxygen species/reactive nitrogen species generation. Phytother Res. 33, 998-1009 (2019) PubMed PMID: 30729588

Yang J, Sun Y, Xu F, Liu W, Mai Y, Hayashi T, Hattori S, Ushiki-Kaku Y, Onodera S, Tashiro SI, Ikejima T. Silibinin ameliorates amylin-induced pancreatic beta-cell apoptosis partly via upregulation of GLP-1R/PKA pathway. Mol Cell Biochem. 452, 83-94 (2019) PubMed PMID: 30022448

Kumazawa Y, Hattori S, Taga Y. Semi-nondestructive certification of crocodilian leather by LC-MS detection of collagen marker peptides. Anal Chem. 91, 1796-1800 (2019) PubMed PMID: 30599131

Xu Q, Liu X, Liu W, Hayashi T, Yamato M, Fujisaki H, Hattori S, Tashiro SI, Onodera S, Ikejima T. Type I collagen-induced YAP nuclear expression promotes primary cilia growth and contributes to cell migration in confluent mouse embryo fibroblast 3T3-L1 cells. Mol Cell Biochem. 450, 87-96 (2019) PubMed PMID: 29846859

Saito S, Sano K, Suzuki T, Ainai A, Taga Y, Ueno T, Tabata K, Saito K, Wada Y, Ohara Y, Takeyama H, Odagiri T, Kageyama T, Ogawa-Goto K, Multihartina P, Setiawaty V, Pangesti KNA, Hasegawa H. IgA tetramerization improves target breadth but not peak potency of functionality of anti-influenza virus broadly neutralizing antibody. PLoS Pathog. 15, e1007427 (2019) PubMed PMID: 30605488

Liu X, Xu Q, Long X, Liu W, Zhao Y, Hayashi T, Hattori S, Fujisaki H, Ogura T, Tashiro SI, Onodera S, Yamato M, Ikejima T. Silibinin-induced autophagy mediated by PPARalpha-sirt1-AMPK pathway participated in the regulation of type I collagen-enhanced migration in murine 3T3-L1 preadipocytes. Mol Cell Biochem. 450, 1-23 (2019) PubMed PMID: 29916120


Taga Y, Kusubata M, Ogawa-Goto K, Hattori S, Funato N. Collagen-derived X-Hyp-Gly-type tripeptides promote differentiation of MC3T3-E1 pre-osteoblasts. J Funct Foods. 46, 456-462 (2018) DOI: 10.1016/j.jff.2018.05.017

Kumazawa Y, Taga Y, Takashima M, Hattori S. A novel LC–MS method using collagen marker peptides for species identification of glue applicable to samples with multiple animal origins. Herit Sci. 6, 43 (2018) DOI: 10.1186/s40494-018-0209-y

Tanaka K, Teramura N, Hayashida O, Iijima K, Okitsu T, Hattori S. The C-terminal segment of collagenase in Grimontia hollisae binds collagen to enhance collagenolysis. FEBS Open Bio. 8, 1691-1702 (2018) PubMed PMID: 30338219

Caviness P, Bauer R, Tanaka K, Janowska K, Roeser JR, Harter D, Sanders J, Ruth C, Matsushita O, Sakon J. Ca(2+) -induced orientation of tandem collagen binding domains from clostridial collagenase ColG permits two opposing functions of collagen fibril formation and retardation. FEBS J. 285, 3254-3269 (2018) PubMed PMID: 30035850

Terauchi Y, Sano K, Ainai A, Saito S, Taga Y, Ogawa-Goto K, Tamura SI, Odagiri T, Tashiro M, Fujieda M, Suzuki T, Hasegawa H. IgA polymerization contributes to efficient virus neutralization on human upper respiratory mucosa after intranasal inactivated influenza vaccine administration. Hum Vaccin Immunother. 14, 1351-1361 (2018) PubMed PMID: 29425074

Fujisaki H, Futaki S, Yamada M, Sekiguchi K, Hayashi T, Ikejima T, Hattori S. Respective optimal calcium concentrations for proliferation on type I collagen fibrils in two keratinocyte line cells, HaCaT and FEPE1L-8. Regen Ther. 8, 73-79 (2018) PubMed PMID: 30271869

Taga Y, Hayashida O, Ashour A, Amen Y, Kusubata M, Ogawa-Goto K, Shimizu K, Hattori S. Characterization of angiotensin-converting enzyme inhibitory activity of X-Hyp-Gly-type tripeptides: importance of collagen-specific prolyl hydroxylation. J Agric Food Chem. 66, 8737-8743 (2018) PubMed PMID: 30060651

Liu X, Long X, Liu W, Zhao Y, Hayashi T, Yamato M, Mizuno K, Fujisaki H, Hattori S, Tashiro SI, Ogura T, Atsuzawa Y, Ikejima T. Type I collagen induces mesenchymal cell differentiation into myofibroblasts through YAP-induced TGF-beta1 activation. Biochimie. 150, 110-130 (2018) PubMed PMID: 29777737

Liu X, Long X, Liu W, Yao G, Zhao Y, Hayashi T, Hattori S, Fujisaki H, Ogura T, Tashiro SI, Onodera S, Yamato M, Ikejima T. Differential levels of reactive oxygen species in murine preadipocyte 3T3-L1 cells cultured on type I collagen molecule-coated and gel-covered dishes exert opposite effects on NF-kappaB-mediated proliferation and migration. Free Radic Res. 52, 913-928 (2018) PubMed PMID: 29768932

Song X, Liu B, Cui L, Zhou B, Liu L, Liu W, Yao G, Xia M, Hayashi T, Hattori S, Ushiki-Kaku Y, Tashiro SI, Ikejima T. Estrogen receptors are involved in the neuroprotective effect of silibinin in abeta1-42-treated rats. Neurochem Res. 43, 796-805 (2018) PubMed PMID: 29397533

Nishikimi A, Koyama YI, Ishihara S, Kobayashi S, Tometsuka C, Kusubata M, Kuwaba K, Hayashida O, Hattori S, Katagiri K. Collagen-derived peptides modulate CD4(+) T-cell differentiation and suppress allergic responses in mice. Immun Inflamm Dis. 6, 245-255 (2018) PubMed PMID: 29388365

Yamauchi M, Taga Y, Hattori S, Shiiba M, Terajima M. Analysis of collagen and elastin cross-links. Methods Cell Biol. 143, 115-132 (2018) PubMed PMID: 29310773

Liu X, Xu Q, Liu W, Yao G, Zhao Y, Xu F, Hayashi T, Fujisaki H, Hattori S, Tashiro SI, Onodera S, Yamato M, Ikejima T. Enhanced migration of murine fibroblast-like 3T3-L1 preadipocytes on type I collagen-coated dish is reversed by silibinin treatment. Mol Cell Biochem. 441, 35-62 (2018) PubMed PMID: 28933025

Xu Q, Liu W, Liu X, Otkur W, Hayashi T, Yamato M, Fujisaki H, Hattori S, Tashiro SI, Ikejima T. Type I collagen promotes primary cilia growth through down-regulating HDAC6-mediated autophagy in confluent mouse embryo fibroblast 3T3-L1 cells. J Biosci Bioeng. 125, 8-14 (2018) PubMed PMID: 28811097

Zhao YL, Lu ZY, Zhang X, Liu WW, Yao GD, Liu XL, Liu W, Wu QJ, Hayashi T, Yamato M, Fujisaki H, Hattori S, Atsuzawa Y, Tashiro SI, Onodera S, Ikejima T. Gelatin promotes cell aggregation and pro-inflammatory cytokine production in PMA-stimulated U937 cells by augmenting endocytosis-autophagy pathway. Int J Biochem Cell Biol. 95, 132-142 (2018) PubMed PMID: 29307663

Kuwaba K, Koyama Y, Hayashida O, Kusubata M, Takara T, Tsukada Y. Safety evaluation of collagen peptide ingestion—Randomized, placebo-controlled, double-blind, parallel-group trial—. Jpn Pharmacol Ther. 46, 1859-1870 (2018) Link

Zhao YL, Liu WW, Liu W, Lu ZY, Xuan DH, Zhang X, Liu XL, Hayashi T, Yamato M, Ogura T, Fujisaki H, Hattori S, Tashiro SI, Onodera S, Ikejima T. Phorbol ester (PMA)-treated U937 cells cultured on type I collagen-coated dish express a lower production of pro-inflammatory cytokines through lowered ROS levels in parallel with cell aggregate formation. Int Immunopharmacol. 55, 158-164 (2018) PubMed PMID: 29253822

Takita T, Qian J, Geng H, He Z, Nemoto S, Mori M, Tanaka K, Hattori S, Kojima K, Yasukawa K. Comparative studies on the activities of collagenases from Grimontia hollisae and Clostridium hystoliticum in the hydrolysis of synthetic substrates. J Biochem. 163, 425-431 (2018) PubMed PMID: 29444248


Ishikawa Y, Mizuno K, Bächinger HP. Ziploc-ing the structure 2.0: Endoplasmic reticulum-resident peptidyl prolyl isomerases show different activities toward hydroxyproline. J Biol Chem. 292, 9273-9282 (2017) PubMed PMID: 28385890

Taga Y, Kusubata M, Ogawa-Goto K, Hattori S. Identification of collagen-derived hydroxyproline (Hyp)-containing cyclic dipeptides with high oral bioavailability: efficient formation of cyclo(X-Hyp) from X-Hyp-Gly-type tripeptides by heating. J Agric Food Chem. 65, 9514-9521 (2017) PubMed PMID: 28988478

Taga Y, Tanaka K, Hamada C, Kusubata M, Ogawa-Goto K, Hattori S. Hydroxyhomocitrulline is a collagen-specific carbamylation mark that affects cross-link formation. Cell Chem Biol. 24, 1276-1284 (2017) PubMed PMID: 28943354

Song X, Liu B, Cui L, Zhou B, Liu W, Xu F, Hayashi T, Hattori S, Ushiki-Kaku Y, Tashiro SI, Ikejima T. Silibinin ameliorates anxiety/depression-like behaviors in amyloid beta-treated rats by upregulating BDNF/TrkB pathway and attenuating autophagy in hippocampus. Physiol Behav. 179, 487-493 (2017) PubMed PMID: 28735062

Terajima M, Taga Y, Cabral WA, Nagasawa M, Sumida N, Hattori S, Marini JC, Yamauchi M. Cyclophilin B deficiency causes abnormal dentin collagen matrix. J Proteome Res. 16, 2914-2923 (2017) PubMed PMID: 28696707

Taga Y, Hayashida O, Kusubata M, Ogawa-Goto K, Hattori S. Production of a novel wheat gluten hydrolysate containing dipeptidyl peptidase-IV inhibitory tripeptides using ginger protease. Biosci Biotechnol Biochem. 81, 1823-1828 (2017) PubMed PMID: 28675098

Nakayama H, Mori M, Takita T, Yasukawa K, Tanaka K, Hattori S, Aikawa H, Hasegawa O, Okamura T, Takegami K, Motokawa S, Kuwahara M, Amano K. Development of immersion vaccine for bacterial cold-water disease in ayu Plecoglossus altivelis. Biosci Biotechnol Biochem. 81, 608-613 (2017) PubMed PMID: 28051913

Song X, Zhou B, Cui L, Lei D, Zhang P, Yao G, Xia M, Hayashi T, Hattori S, Ushiki-Kaku Y, Tashiro SI, Onodera S, Ikejima T. Silibinin ameliorates Abeta25-35-induced memory deficits in rats by modulating autophagy and attenuating neuroinflammation as well as oxidative stress. Neurochem Res. 42, 1073-1083 (2017) PubMed PMID: 28004303

Qian J, Ito S, Satoh J, Geng H, Tanaka K, Hattori S, Kojima K, Takita T, Yasukawa K. The cleavage site preference of the porcine pepsin on the N-terminal alpha1 chain of bovine type I collagen: a focal analysis with mass spectrometry. Biosci Biotechnol Biochem. 81, 514-522 (2017) PubMed PMID: 27931164

Wang HJ, Li MQ, Liu WW, Hayashi T, Fujisaki H, Hattori S, Tashiro SI, Onodera S, Ikejima T. Collagen gel protects L929 cells from TNFalpha-induced death by activating NF-kappaB. Connect Tissue Res. 58, 456-463 (2017) PubMed PMID: 27764545

Tometsuka C, Koyama YI, Ishijima T, Toyoda T, Teranishi M, Takehana K, Abe K, Nakai Y. Collagen peptide ingestion alters lipid metabolism-related gene expression and the unfolded protein response in mouse liver. Br J Nutr. 117, 1-11 (2017) PubMed PMID: 28091360

Miyazawa K, Masujin K, Okada H, Ushiki-Kaku Y, Matsuura Y, Yokoyama T. Selective propagation of mouse-passaged scrapie prions with long incubation period from a mixed prion population using GT1-7 cells. PLoS One. 12, e0179317 (2017) PubMed PMID: 28636656


Qian J, Okada Y, Ogura T, Tanaka K, Hattori S, Ito S, Satoh J, Takita T, Yasukawa K. Kinetic analysis of the digestion of bovine type I collagen telopeptides with porcine pepsin. J Food Sci. 81, C27-34 (2016) PubMed PMID: 26661326

Taga Y, Kusubata M, Ogawa-Goto K, Hattori S. Developmental stage-dependent regulation of prolyl 3-hydroxylation in tendon type I collagen. J Biol Chem. 291, 837-847 (2016) PubMed PMID: 26567337

Kumazawa Y, Taga Y, Iwai K, Koyama Y. A rapid and simple LC-MS method using collagen marker peptides for identification of the animal source of leather. J Agric Food Chem. 64, 6051-6057 (2016) PubMed PMID: 27397145

Sekiguchi H, Uchida K, Inoue G, Matsushita O, Saito W, Aikawa J, Tanaka K, Fujimaki H, Miyagi M, Takaso M. Acceleration of bone formation during fracture healing by poly(pro-hyp-gly)10 and basic fibroblast growth factor containing polycystic kidney disease and collagen-binding domains from Clostridium histolyticum collagenase. J Biomed Mater Res A. 104, 1372-1378 (2016) PubMed PMID: 26833780

Koyama Y. Effects of collagen ingestion and their biological significance. J Nutr Food Sci. 6, 504 (2016) DOI: 10.4172/2155-9600.1000504

Nakayama H, Tanaka K, Teramura N, Hattori S. Expression of collagenase in Flavobacterium psychrophilum isolated from cold-water disease-affected ayu (Plecoglossus altivelis). Biosci Biotechnol Biochem. 80, 135-144 (2016) PubMed PMID: 26327168

Taga Y, Kusubata M, Ogawa-Goto K, Hattori S. Efficient absorption of X-hydroxyproline (Hyp)-Gly after oral administration of a novel gelatin hydrolysate prepared using ginger protease. J Agric Food Chem. 64, 2962-2970 (2016) PubMed PMID: 26978646

Terajima M, Taga Y, Chen Y, Cabral WA, Hou-Fu G, Srisawasdi S, Nagasawa M, Sumida N, Hattori S, Kurie JM, Marini JC, Yamauchi M. Cyclophilin-B modulates collagen cross-linking by differentially affecting lysine hydroxylation in the helical and telopeptidyl domains of tendon type I collagen. J Biol Chem. 291, 9501-9512 (2016) PubMed PMID: 26934917


Hirose T, Ogura T, Tanaka K, Minaguchi J, Yamauchi T, Fukada T, Koyama Y, Takehana K. Comparative study of dermal components and plasma TGF-beta1 levels in Slc39a13/Zip13-KO mice. J Vet Med Sci. 77, 1385-1389 (2015) PubMed PMID: 26050750

Watanabe T, Nishimura K, Takeuchi R, Koyama Y, Kusubata M, Takehana K, Hiramatsu K. Oral ingestion of collagen peptide causes change in width of the perimysium of the chicken iliotibialis lateralis muscle. J Vet Med Sci. 77, 1413-1417 (2015) PubMed PMID: 26050842

Terao K, Kanenaga R, Yoshida T, Mizuno K, Bächinger HP. Temperature induced complex formation-deformation behavior of collagen model peptides and polyelectrolytes in aqueous solution. Polymer. 64, 8-13 (2015) DOI: 10.1016/j.polymer.2015.03.013

Koyama Y, Kuwaba K, Kusubata M, Hayashida O, Takara T, Tsukada Y. Supplemental ingestion of collagen peptide improves T-cell-related human immune status—Placebo-controlled double-blind study—. Jpn Pharmacol Ther. 43, 51-56 (2015) Link

Ohno M, Ito K, Lan VT, Kusubata M, Tometsuka C, Koyama Y, Motoyama T, Ito S, Kawarasaki Y. Synergistic inhibition of human dipeptidyl peptidase IV by combinations of peptides. Peptides. 69, 115-117 (2015) PubMed PMID: 25929171

Kusubata M, Koyama Y, Tometsuka C, Shigemura Y, Sato K. Detection of endogenous and food-derived collagen dipeptide prolylhydroxyproline (Pro-Hyp) in allergic contact dermatitis-affected mouse ear. Biosci Biotechnol Biochem. 79, 1356-1361 (2015) PubMed PMID: 25848885

Kobayashi K, Maehata Y, Okada Y, Kusubata M, Hattori S, Tanaka K, Miyamoto C, Yoshino F, Yoshida A, Tokutomi F, Wada-Takahashi S, Komatsu T, Otsuka T, Takahashi SS, Lee MC. Medical-grade collagen peptide in injectables provides antioxidant protection. Pharm Dev Technol. 20, 219-226 (2015) PubMed PMID: 24286241

Wang HJ, He WQ, Chen L, Liu WW, Xu Q, Xia MY, Hayashi T, Fujisaki H, Hattori S, Tashiro S, Onodera S, Ikejima T. Type I collagen gel protects murine fibrosarcoma L929 cells from TNFalpha-induced cell death. Biochem Biophys Res Commun. 457, 693-699 (2015) PubMed PMID: 25619136


Iijima K, Sasaki M, Taga Y, Hattori S. Cross conversion between Nω-carboxymethylarginine (CMA) and glyoxal derived hydroimidazolones (G-Hs). IMARS Highlights. 9, 29-36 (2014) Link

Noritake K, Kuroda S, Nyan M, Atsuzawa Y, Uo M, Ohya K, Kasugai S. Use of a gelatin hydrogel membrane containing beta-tricalcium phosphate for guided bone regeneration enhances rapid bone formation. Dent Mater J. 33, 674-680 (2014) PubMed PMID: 25273048

Taga Y, Kusubata M, Ogawa-Goto K, Hattori S. Highly accurate quantification of hydroxyproline-containing peptides in blood using a protease digest of stable isotope-labeled collagen. J Agric Food Chem. 62, 12096-12102 (2014) PubMed PMID: 25417748

Taga Y, Kusubata M, Ogawa-Goto K, Hattori S. Stable isotope-labeled collagen: a novel and versatile tool for quantitative collagen analyses using mass spectrometry. J Proteome Res. 13, 3671-3678 (2014) PubMed PMID: 24953783

Koyama Y, Kuwaba K, Kondo S, Tsukada Y. Supplemental ingestion of collagen peptide suppresses ultraviolet-induced erythema—A randomized double-blind placebo-controlled study—. Jpn Pharmacol Ther. 42, 781-790 (2014) Link

Shibuya S, Ozawa Y, Toda T, Watanabe K, Tometsuka C, Ogura T, Koyama Y, Shimizu T. Collagen peptide and vitamin C additively attenuate age-related skin atrophy in Sod1-deficient mice. Biosci Biotechnol Biochem. 78, 1212-1220 (2014) PubMed PMID: 25229861

Saito W, Uchida K, Ueno M, Matsushita O, Inoue G, Nishi N, Ogura T, Hattori S, Fujimaki H, Tanaka K, Takaso M. Acceleration of bone formation during fracture healing by injectable collagen powder and human basic fibroblast growth factor containing a collagen-binding domain from Clostridium histolyticum collagenase. J Biomed Mater Res A. 102, 3049-3055 (2014) PubMed PMID: 24124060

Uchida K, Matsushita O, Naruse K, Mima T, Nishi N, Hattori S, Ogura T, Inoue G, Tanaka K, Takaso M. Acceleration of periosteal bone formation by human basic fibroblast growth factor containing a collagen-binding domain from Clostridium histolyticum collagenase. J Biomed Mater Res A. 102, 1737-1743 (2014) PubMed PMID: 23775724

Ushiki-Kaku Y, Shimizu Y, Tabeta N, Iwamaru Y, Ogawa-Goto K, Hattori S, Yokoyama T. Heterogeneity of abnormal prion protein (PrP(Sc)) in murine scrapie prions determined by PrP(Sc)-specific monoclonal antibodies. J Vet Med Sci. 76, 285-288 (2014) PubMed PMID: 24132297


Taga Y, Kusubata M, Ogawa-Goto K, Hattori S. Site-specific quantitative analysis of overglycosylation of collagen in osteogenesis imperfecta using hydrazide chemistry and SILAC. J Proteome Res. 12, 2225-2232 (2013) PubMed PMID: 23581850

Ushiki-Kaku Y, Iwamaru Y, Masujin K, Imamura M, Itohara S, Ogawa-Goto K, Hattori S, Yokoyama T. Different antigenicities of the N-terminal region of cellular and scrapie prion proteins. Microbiol Immunol. 57, 792-796 (2013) PubMed PMID: 24117858

Yamamoto T, Ushiki-Kaku Y, Yokoyama T, Hattori S. Sensitivity and specificity of a commercial BSE kit for the detection of ovine scrapie. Anim Sci J. 84, 508-512 (2013) PubMed PMID: 23607323

Pokidysheva E, Zientek KD, Ishikawa Y, Mizuno K, Vranka JA, Montgomery NT, Keene DR, Kawaguchi T, Okuyama K, Bachinger HP. Posttranslational modifications in type I collagen from different tissues extracted from wild type and prolyl 3-hydroxylase 1 null mice. J Biol Chem. 288, 24742-24752 (2013) PubMed PMID: 23861401

Okuyama K, Kawaguchi T, Shimura M, Noguchi K, Mizuno K, Bachinger HP. Crystal structure of the collagen model peptide (Pro-Pro-Gly)4-Hyp-Asp-Gly-(Pro-Pro-Gly)4 at 1.0 A resolution. Biopolymers. 99, 436-447 (2013) PubMed PMID: 23616212

Mizuno K, Boudko S, Engel J, Bachinger HP. Vascular Ehlers-Danlos syndrome mutations in type III collagen differently stall the triple helical folding. J Biol Chem. 288, 19166-19176 (2013) PubMed PMID: 23645670

Koyama Y, Kusubata M. Effects of collagen peptide ingestion on blood lipids in rats fed a high-lipid and high-sucrose diet. Food Sci Technol Res. 19, 1149-1153 (2013) DOI: 10.3136/fstr.19.1149

Yuda Y, Kasashima Y, Kuwano A, Sato K, Hattori S, Arai K. Active hyaluronidase 2 expression in the granulation tissue formed in the healing process of equine superficial digital flexor tendonitis. J Vet Med Sci. 75, 219-223 (2013) PubMed PMID: 23047331


Ogawa-Goto K, Ueno T, Oshima K, Yamamoto H, Sasaki J, Fujita K, Sata T, Taniguchi S, Kanda Y, Katano H. Detection of active human cytomegalovirus by the promyelocytic leukemia body assay in cultures of PBMCs from patients undergoing hematopoietic stem cell transplantation. J Med Virol. 84, 479-486 (2012) PubMed PMID: 22246835

Yamamoto T, Nakashima K, Maruta Y, Kiriyama T, Sasaki M, Sugiyama S, Suzuki K, Fujisaki H, Sasaki J, Kaku-Ushiki Y, Tanida M, Irie S, Hattori S. Improved RNA extraction method using the BioMasher and BioMasher power-plus. J Vet Med Sci. 74, 1561-1567 (2012) PubMed PMID: 22813946

Takahashi T, Kondo T, Tanaka K, Hattori S, Irie S, Kudoh S, Imura S, Kanda H. Measurement of solar UV radiation in Antarctica with collagen sheets. Photochem Photobiol Sci. 11, 1193-1200 (2012) PubMed PMID: 22419356

Ueno T, Kaneko K, Sata T, Hattori S, Ogawa-Goto K. Regulation of polysome assembly on the endoplasmic reticulum by a coiled-coil protein, p180. Nucleic Acids Res. 40, 3006-3017 (2012) PubMed PMID: 22156060

Taga Y, Kusubata M, Ogawa-Goto K, Hattori S. Development of a novel method for analyzing collagen O-glycosylations by hydrazide chemistry. Mol Cell Proteomics. 11, M111 010397 (2012) PubMed PMID: 22247541

Minaguchi J, Tometsuka C, Koyama Y, Kusubata M, Nagayasu A, Sawaya S, Shiga T, Shima H, Hara T, Takehana K. Effects of collagen-derived oligopeptide prolylhydroxyproline on differentiation of mouse 3T3-L1 preadipocytes. Food Sci Technol Res. 18, 593-599 (2012) DOI: 10.3136/fstr.18.593


Teramura N, Tanaka K, Iijima K, Hayashida O, Suzuki K, Hattori S, Irie S. Cloning of a novel collagenase gene from the gram-negative bacterium Grimontia (Vibrio) hollisae 1706B and its efficient expression in Brevibacillus choshinensis. J Bacteriol. 193, 3049-3056 (2011) PubMed PMID: 21515782

Kobayashi K, Maehata Y, Kawamura Y, Kusubata M, Hattori S, Tanaka K, Miyamoto C, Yoshino F, Yoshida A, Wada-Takahashi S, Komatsu T, Takahashi SS, Lee MC. Direct assessments of the antioxidant effects of the novel collagen peptide on reactive oxygen species using electron spin resonance spectroscopy. J Pharmacol Sci. 116, 97-106 (2011) PubMed PMID: 21512306

Sasaki J, Fujisaki H, Adachi E, Irie S, Hattori S. Delay of cell cycle progression and induction death of cancer cells on type I collagen fibrils [corrected]. Connect Tissue Res. 52, 167-177 (2011) PubMed PMID: 20672981


Ueno T, Tanaka K, Kaneko K, Taga Y, Sata T, Irie S, Hattori S, Ogawa-Goto K. Enhancement of procollagen biosynthesis by p180 through augmented ribosome association on the endoplasmic reticulum in response to stimulated secretion. J Biol Chem. 285, 29941-29950 (2010) PubMed PMID: 20647306

Ushiki-Kaku Y, Endo R, Iwamaru Y, Shimizu Y, Imamura M, Masujin K, Yamamoto T, Hattori S, Itohara S, Irie S, Yokoyama T. Tracing conformational transition of abnormal prion proteins during interspecies transmission by using novel antibodies. J Biol Chem. 285, 11931-11936 (2010) PubMed PMID: 20177064

Shimizu Y, Kaku-Ushiki Y, Iwamaru Y, Muramoto T, Kitamoto T, Yokoyama T, Mohri S, Tagawa Y. A novel anti-prion protein monoclonal antibody and its single-chain fragment variable derivative with ability to inhibit abnormal prion protein accumulation in cultured cells. Microbiol Immunol. 54, 112-121 (2010) PubMed PMID: 20377745

Hosseinkhani H, Hosseinkhani M, Hattori S, Matsuoka R, Kawaguchi N. Micro and nano-scale in vitro 3D culture system for cardiac stem cells. J Biomed Mater Res A. 94, 1-8 (2010) PubMed PMID: 20014298

Yonezawa T, Hattori S, Inagaki J, Kurosaki M, Takigawa T, Hirohata S, Miyoshi T, Ninomiya Y. Type IV collagen induces expression of thrombospondin-1 that is mediated by integrin alpha1beta1 in astrocytes. Glia. 58, 755-767 (2010) PubMed PMID: 20091789

Fujita K, Teramura N, Hattori S, Irie S, Mitsunaga-Nakatsubo K, Akimoto Y, Sakamoto N, Yamamoto T, Akasaka K. Mammalian arylsulfatase A functions as a novel component of the extracellular matrix. Connect Tissue Res. 51, 388-396 (2010) PubMed PMID: 20297902

Li S, Shimono C, Norioka N, Nakano I, Okubo T, Yagi Y, Hayashi M, Sato Y, Fujisaki H, Hattori S, Sugiura N, Kimata K, Sekiguchi K. Activin A binds to perlecan through its pro-region that has heparin/heparan sulfate binding activity. J Biol Chem. 285, 36645-36655 (2010) PubMed PMID: 20843788

Ueno T, Kaneko K, Katano H, Sato Y, Mazitschek R, Tanaka K, Hattori S, Irie S, Sata T, Ogawa-Goto K. Expansion of the trans-Golgi network following activated collagen secretion is supported by a coiled-coil microtubule-bundling protein, p180, on the ER. Exp Cell Res. 316, 329-340 (2010) PubMed PMID: 19932094


Tanaka K, Ebihara T, Kusubata M, Adachi E, Arai M, Kawaguchi N, Utsunomiya J, Miki Y, Hiramoto M, Hattori S, Irie S. Abnormal collagen deposition in fibromas from patient with juvenile hyaline fibromatosis. J Dermatol Sci. 55, 197-200 (2009) PubMed PMID: 19592224

Tanaka M, Koyama Y, Nomura Y. Effects of collagen peptide ingestion on UV-B-induced skin damage. Biosci Biotechnol Biochem. 73, 930-932 (2009) PubMed PMID: 19352014

Ueno T, Ogawa-Goto K. Use of a GFP-PML-expressing cell line as a biosensor for human cytomegalovirus infection. Methods Mol Biol. 515, 33-44 (2009) PubMed PMID: 19378119


Iwamaru Y, Shimizu Y, Imamura M, Murayama Y, Endo R, Tagawa Y, Ushiki-Kaku Y, Takenouchi T, Kitani H, Mohri S, Yokoyama T, Okada H. Lactoferrin induces cell surface retention of prion protein and inhibits prion accumulation. J Neurochem. 107, 636-646 (2008) PubMed PMID: 18717818

Fujisaki H, Adachi E, Hattori S. Keratinocyte differentiation and proliferation are regulated by adhesion to the three-dimensional meshwork structure of type IV collagen. Connect Tissue Res. 49, 426-436 (2008) PubMed PMID: 19085243

Yamamoto T, Ushiki Y, Hara S, Hall WW, Tsukagoshi-Nagai H, Yokoyama T, Tagawa Y, Sata T, Yamakawa Y, Kinoshita N, Tamura F, Hattori S, Irie S. An advantageous method utilizing new homogenizing device BioMasher and a sensitive ELISA to detect bovine spongiform encephalopathy accurately in brain tissue. J Virol Methods. 149, 316-325 (2008) PubMed PMID: 18346796


Fujisaki H, Ebihara T, Irie S, Kobayashi T, Adachi E, Mochitate K, Hattori S. Keratinocyte apoptosis on type I collagen fibrils is prevented by Erk1/2 activation under high calcium condition. Connect Tissue Res. 48, 159-169 (2007) PubMed PMID: 17522999

Sano K, Asanuma-Date K, Arisaka F, Hattori S, Ogawa H. Changes in glycosylation of vitronectin modulate multimerization and collagen binding during liver regeneration. Glycobiology. 17, 784-794 (2007) PubMed PMID: 17369286

Iijima K, Fujimoto D, Irie S. Amount of N(omega)-(Carboxymethyl)arginine generated in collagen and bovine serum albumin during glycation reactions is significantly different. Connect Tissue Res. 48, 271-276 (2007) PubMed PMID: 17882703

Ogawa-Goto K, Tanaka K, Ueno T, Tanaka K, Kurata T, Sata T, Irie S. p180 is involved in the interaction between the endoplasmic reticulum and microtubules through a novel microtubule-binding and bundling domain. Mol Biol Cell. 18, 3741-3751 (2007) PubMed PMID: 17634287


Matsuda N, Koyama Y, Hosaka Y, Ueda H, Watanabe T, Araya T, Irie S, Takehana K. Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis. J Nutr Sci Vitaminol (Tokyo). 52, 211-215 (2006) PubMed PMID: 16967766

Ueno T, Eizuru Y, Katano H, Kurata T, Sata T, Irie S, Ogawa-Goto K. Novel real-time monitoring system for human cytomegalovirus-infected cells in vitro that uses a green fluorescent protein-PML-expressing cell line. Antimicrob Agents Chemother. 50, 2806-2813 (2006) PubMed PMID: 16870775

Ino T, Hattori M, Yoshida T, Hattori S, Yoshimura K, Takahashi K. Improved physical and biochemical features of a collagen membrane by conjugating with soluble egg shell membrane protein. Biosci Biotechnol Biochem. 70, 865-873 (2006) PubMed PMID: 16636453

Kitamori K, Kobayashi M, Akamatsu H, Hirota-Sakashita A, Kusubata M, Irie S, Koyama Y. Weakness in intercellular association of keratinocytes in severely brittle nails. Arch Histol Cytol. 69, 323-328 (2006) PubMed PMID: 17372388


Hayashi HK, Yokoyama T, Takata M, Iwamaru Y, Imamura M, Ushiki YK, Shinagawa M. The N-terminal cleavage site of PrPSc from BSE differs from that of PrPSc from scrapie. Biochem Biophys Res Commun. 328, 1024-1027 (2005) PubMed PMID: 15707980

Miura-Yokota Y, Matsubara Y, Ebihara T, Koyama Y, Ogawa-Goto K, Isobe N, Hattori S, Irie S. Cloning and nucleotide sequence of a novel 28-kDa protein from the mantle muscle of the squid Todarodes pacificus with homology to tropomyosin. Comp Biochem Physiol B Biochem Mol Biol. 141, 3-12 (2005) PubMed PMID: 15820129

Minaguchi J, Koyama Y, Meguri N, Hosaka Y, Ueda H, Kusubata M, Hirota A, Irie S, Mafune N, Takehana K. Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in Achilles tendon. J Nutr Sci Vitaminol (Tokyo). 51, 169-174 (2005) PubMed PMID: 16161767


Kajimura D, Takahashi S, Yoshikawa K, Hattori S, Sado Y, Imamura Y, Hayashi T. Non-helical type IV collagen polypeptides in human placenta. Biochem Biophys Res Commun. 314, 11-16 (2004) PubMed PMID: 14715239

Hayashi H, Takata M, Iwamaru Y, Ushiki Y, Kimura KM, Tagawa Y, Shinagawa M, Yokoyama T. Effect of tissue deterioration on postmortem BSE diagnosis by immunobiochemical detection of an abnormal isoform of prion protein. J Vet Med Sci. 66, 515-520 (2004) PubMed PMID: 15187361

Miura-Yokota Y, Matsubara Y, Ebihara T, Hattori S, Irie S. A cysteine-activated protease isolated from Todarodes pacificus squid degrades collagen below its denaturation temperature. Connect Tissue Res. 45, 109-121 (2004) PubMed PMID: 15763926

Hirano S, Yonezawa T, Hasegawa H, Hattori S, Greenhill NS, Davis PF, Sage EH, Ninomiya Y. Astrocytes express type VIII collagen during the repair process of brain cold injury. Biochem Biophys Res Commun. 317, 437-443 (2004) PubMed PMID: 15063777

Mimura T, Yamagami S, Yokoo S, Usui T, Tanaka K, Hattori S, Irie S, Miyata K, Araie M, Amano S. Cultured human corneal endothelial cell transplantation with a collagen sheet in a rabbit model. Invest Ophthalmol Vis Sci. 45, 2992-2997 (2004) PubMed PMID: 15326112

Suzuki Y, Hattori S, Isemura M. Epigallocatechin-3-O-gallate inhibits fibroblast contraction of floating collagen gel: interaction between epigallocatechin-3-O-gallate and platelet derived growth factor. Biosci Biotechnol Biochem. 68, 1817-1820 (2004) PubMed PMID: 15322374

Sato K, Hattori S, Irie S, Sorimachi H, Inomata M, Kawashima S. Degradation of fodrin by m-calpain in fibroblasts adhering to fibrillar collagen I gel. J Biochem. 136, 777-785 (2004) PubMed PMID: 15671488


Hirota A, Ebihara T, Kusubata M, Kobayashi M, Kobayashi K, Kuwaba K, Tanaka K, Kiriyama T, Irie S, Koyama Y. Collagen of chronically inflamed skin is over-modified and upregulates secretion of matrix metalloproteinase 2 and matrix-degrading enzymes by endothelial cells and fibroblasts. J Invest Dermatol. 121, 1317-1325 (2003) PubMed PMID: 14675176

Ogawa-Goto K, Tanaka K, Gibson W, Moriishi E, Miura Y, Kurata T, Irie S, Sata T. Microtubule network facilitates nuclear targeting of human cytomegalovirus capsid. J Virol. 77, 8541-8547 (2003) PubMed PMID: 12857923

Kobayashi T, Hattori S, Shinkai H. Matrix metalloproteinases-2 and -9 are secreted from human fibroblasts. Acta Derm Venereol. 83, 105-107 (2003) PubMed PMID: 12735637

Sato K, Hattori S, Irie S, Kawashima S. Spike formation by fibroblasts adhering to fibrillar collagen I gel. Cell Struct Funct. 28, 229-241 (2003) PubMed PMID: 14586133


Hattori S, Fujisaki H, Kiriyama T, Yokoyama T, Irie S. Real-time zymography and reverse zymography: a method for detecting activities of matrix metalloproteinases and their inhibitors using FITC-labeled collagen and casein as substrates. Anal Biochem. 301, 27-34 (2002) PubMed PMID: 11811964

Ogawa-Goto K, Irie S, Omori A, Miura Y, Katano H, Hasegawa H, Kurata T, Sata T, Arao Y. An endoplasmic reticulum protein, p180, is highly expressed in human cytomegalovirus-permissive cells and interacts with the tegument protein encoded by UL48. J Virol. 76, 2350-2362 (2002) PubMed PMID: 11836413

Sugaya M, Nakamura K, Watanabe T, Asahina A, Yasaka N, Koyama Y, Kusubata M, Ushiki Y, Kimura K, Morooka A, Irie S, Yokoyama T, Inoue K, Itohara S, Tamaki K. Expression of cellular prion-related protein by murine Langerhans cells and keratinocytes. J Dermatol Sci. 28, 126-134 (2002) PubMed PMID: 11858951

Watanabe K, Hattori S. Real-time dual zymographic analysis of matrix metalloproteinases using fluorescein-isothiocyante-labeled gelatin and Texas-red-labeled casein. Anal Biochem. 307, 390-392 (2002) PubMed PMID: 12202261

Hazeki N, Tsukamoto T, Yazawa I, Koyama M, Hattori S, Someki I, Iwatsubo T, Nakamura K, Goto J, Kanazawa I. Ultrastructure of nuclear aggregates formed by expressing an expanded polyglutamine. Biochem Biophys Res Commun. 294, 429-440 (2002) PubMed PMID: 12051730

Hori H, Hattori S, Inouye S, Kimura A, Irie S, Miyazawa H, Sakaguchi M. Analysis of the major epitope of the alpha2 chain of bovine type I collagen in children with bovine gelatin allergy. J Allergy Clin Immunol. 110, 652-657 (2002) PubMed PMID: 12373276

Fujisaki H, Hattori S. Keratinocyte apoptosis on type I collagen gel caused by lack of laminin 5/10/11 deposition and Akt signaling. Exp Cell Res. 280, 255-269 (2002) PubMed PMID: 12413891

Kuwaba K, Kobayashi M, Nomura Y, Irie S, Koyama Y. Size control of decorin dermatan sulfate during remodeling of collagen fibrils in healing skin. J Dermatol Sci. 29, 185-194 (2002) PubMed PMID: 12234708


Takai KK, Hattori S, Irie S. Type V collagen distribution in liver is reconstructed in coculture system of hepatocytes and stellate cells; the possible functions of type V collagen in liver under normal and pathological conditions. Cell Struct Funct. 26, 289-302 (2001) PubMed PMID: 11831361

Kobayashi T, Nishikawa T, Hattori S, Yoshida N, Takagi T, Watanabe H, Hori H, Nagai Y. Systematic separation and purification of elastase, gelatinase (matrix metalloproteinase 9), and collagenase (matrix metalloproteinase 8) from polymorphonuclear leukocytes in dialyzers previously used by patients with renal failure. Protein Expr Purif. 22, 45-51 (2001) PubMed PMID: 11388798

Kuwaba K, Kobayashi M, Nomura Y, Irie S, Koyama Y. Elongated dermatan sulphate in post-inflammatory healing skin distributes among collagen fibrils separated by enlarged interfibrillar gaps. Biochem J. 358, 157-163 (2001) PubMed PMID: 11485563

Odani H, Iijima K, Nakata M, Miyata S, Kusunoki H, Yasuda Y, Hiki Y, Irie S, Maeda K, Fujimoto D. Identification of N(omega)-carboxymethylarginine, a new advanced glycation endproduct in serum proteins of diabetic patients: possibility of a new marker of aging and diabetes. Biochem Biophys Res Commun. 285, 1232-1236 (2001) PubMed PMID: 11478788

Nadanaka S, Sato C, Kitajima K, Katagiri K, Irie S, Yamagata T. Occurrence of oligosialic acids on integrin alpha 5 subunit and their involvement in cell adhesion to fibronectin. J Biol Chem. 276, 33657-33664 (2001) PubMed PMID: 11418585

Katano H, Ogawa-Goto K, Hasegawa H, Kurata T, Sata T. Human-herpesvirus-8-encoded K8 protein colocalizes with the promyelocytic leukemia protein (PML) bodies and recruits p53 to the PML bodies. Virology. 286, 446-455 (2001) PubMed PMID: 11485412

Yokoyama T, Kimura KM, Ushiki Y, Yamada S, Morooka A, Nakashiba T, Sassa T, Itohara S. In vivo conversion of cellular prion protein to pathogenic isoforms, as monitored by conformation-specific antibodies. J Biol Chem. 276, 11265-11271 (2001) PubMed PMID: 11152682

Hyuga S, Kawasaki N, Hyuga M, Ohta M, Shibayama R, Kawanishi T, Yamagata S, Yamagata T, Hayakawa T. Ganglioside GD1a inhibits HGF-induced motility and scattering of cancer cells through suppression of tyrosine phosphorylation of c-Met. Int J Cancer. 94, 328-334 (2001) PubMed PMID: 11745410

Koyama Y, Hirota A, Mori H, Takahara H, Kuwaba K, Kusubata M, Matsubara Y, Kasugai S, Itoh M, Irie S. Ingestion of gelatin has differential effect on bone mineral density and body weight in protein undernutrition. J Nutr Sci Vitaminol (Tokyo). 47, 84-86 (2001) PubMed PMID: 11349896

Tsuji-Yamada J, Nakazawa M, Takahashi K, Iijima K, Hattori S, Okuda K, Minami M, Ikezawa Z, Sasaki T. Effect of IL-12 encoding plasmid administration on tight-skin mouse. Biochem Biophys Res Commun. 280, 707-712 (2001) PubMed PMID: 11162578


Katagiri K, Hattori M, Minato N, Irie S, Takatsu K, Kinashi T. Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase. Mol Cell Biol. 20, 1956-1969 (2000) PubMed PMID: 10688643

Watanabe K, Takahashi H, Habu Y, Kamiya-Kubushiro N, Kamiya S, Nakamura H, Yajima H, Ishii T, Katayama T, Miyazaki K, Fukai F. Interaction with heparin and matrix metalloproteinase 2 cleavage expose a cryptic anti-adhesive site of fibronectin. Biochemistry. 39, 7138-7144 (2000) PubMed PMID: 10852711

Sato K, Ebihara T, Adachi E, Kawashima S, Hattori S, Irie S. The reconstituted type I collagen fibrils from skins of variously aged bovines exert different effects on the morphology and integrin a2b1 expression of fibroblasts in culture. Connect Tissue. 32, 1-10 (2000) Link

Sato K, Ebihara T, Adachi E, Kawashima S, Hattori S, Irie S. Possible involvement of aminotelopeptide in self-assembly and thermal stability of collagen I as revealed by its removal with proteases. J Biol Chem. 275, 25870-25875 (2000) PubMed PMID: 10851240

Kobayashi T, Hattori S, Nagai Y, Tajima S. Differential regulation of the secretions of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 from human keratinocytes in culture. IUBMB Life. 50, 221-226 (2000) PubMed PMID: 11142351

Ueoka C, Kaneda N, Okazaki I, Nadanaka S, Muramatsu T, Sugahara K. Neuronal cell adhesion, mediated by the heparin-binding neuroregulatory factor midkine, is specifically inhibited by chondroitin sulfate E. Structural ans functional implications of the over-sulfated chondroitin sulfate. J Biol Chem. 275, 37407-37413 (2000) PubMed PMID: 10978312

Sakaguchi M, Toda M, Ebihara T, Irie S, Hori H, Imai A, Yanagida M, Miyazawa H, Ohsuna H, Ikezawa Z, Inouye S. IgE antibody to fish gelatin (type I collagen) in patients with fish allergy. J Allergy Clin Immunol. 106, 579-584 (2000) PubMed PMID: 10984381

Iijima K, Murata M, Takahara H, Irie S, Fujimoto D. Identification of N(omega)-carboxymethylarginine as a novel acid-labileadvanced glycation end product in collagen. Biochem J. 347 Pt 1, 23-27 (2000) PubMed PMID: 10727397

Koyama Y, Norose-Toyoda K, Hirano S, Kobayashi M, Ebihara T, Someki I, Fujisaki H, Irie S. Type I collagen is a non-adhesive extracellular matrix for macrophages. Arch Histol Cytol. 63, 71-79 (2000) PubMed PMID: 10770590


Yajima H, Watanabe K, Takemura T, Ishii T. Inhibitory effect of the conformation of amylose as a function of I2 concentration on glucoamylase activity. Biosci Biotechnol Biochem. 63, 1011-1016 (1999) PubMed PMID: 27389335

Kuwaba K, Nomura Y, Irie S, Koyama Y. Temporal changes in disaccharide composition of dermatan sulfate in the skin after epicutaneous application of hapten. J Dermatol Sci. 19, 23-30 (1999) PubMed PMID: 9890371

Watanabe K, Koyama Y. Adhesion of macrophages on collagen irradiated with ultraviolet light. J Biomater Sci Polym Ed. 10, 351-361 (1999) PubMed PMID: 10189103

Sakaguchi M, Hori H, Ebihara T, Irie S, Yanagida M, Inouye S. Reactivity of the immunoglobulin E in bovine gelatin-sensitive children to gelatins from various animals. Immunology. 96, 286-290 (1999) PubMed PMID: 10233707

Yoneda C, Hirayama Y, Nakaya M, Matsubara Y, Irie S, Hatae K, Watabe S. The occurrence of two types of collagen proalpha-chain in the abalone Haliotis discus muscle. Eur J Biochem. 261, 714-721 (1999) PubMed PMID: 10215888

Nadanaka S, Kitagawa H, Goto F, Tamura J, Neumann KW, Ogawa T, Sugahara K. Involvement of the core protein in the first beta-N-acetylgalactosamine transfer to the glycosaminoglycan-protein linkage-region tetrasaccharide and in the subsequent polymerization: the critical determining step for chondroitin sulphate biosynthesis. Biochem J. 340 ( Pt 2), 353-357 (1999) PubMed PMID: 10333474

Nadanaka S, Fujita M, Sugahara K. Demonstration of a novel sulfotransferase in fetal bovine serum, which transfers sulfate to the C6 position of the GalNAc residue in the sequence iduronic acid alpha1-3GalNAc beta1-4iduronic acid in dermatan sulfate. FEBS Lett. 452, 185-189 (1999) PubMed PMID: 10386587

Ueoka C, Nadanaka S, Seno N, Khoo KH, Sugahara K. Structural determination of novel tetra- and hexasaccharide sequences isolated from chondroitin sulfate H (oversulfated dermatan sulfate) of hagfish notochord. Glycoconj J. 16, 291-305 (1999) PubMed PMID: 10579698

Kusubata M, Hirota A, Ebihara T, Kuwaba K, Matsubara Y, Sasaki T, Kusakabe M, Tsukada T, Irie S, Koyama Y. Spatiotemporal changes of fibronectin, tenascin-C, fibulin-1, and fibulin-2 in the skin during the development of chronic contact dermatitis. J Invest Dermatol. 113, 906-912 (1999) PubMed PMID: 10594729

Salgado CG, Nakamura K, Sugaya M, Tada Y, Asahina A, Koyama Y, Irie S, Tamaki K. Functional CD40 ligand is expressed on epidermal Langerhans cells. J Leukoc Biol. 66, 281-285 (1999) PubMed PMID: 10449168

Salgado CG, Nakamura K, Sugaya M, Tada Y, Asahina A, Fukuda S, Koyama Y, Irie S, Tamaki K. Differential effects of cytokines and immunosuppressive drugs on CD40, B7-1, and B7-2 expression on purified epidermal Langerhans cells1. J Invest Dermatol. 113, 1021-1027 (1999) PubMed PMID: 10594746

Hattori S, Adachi E, Ebihara T, Shirai T, Someki I, Irie S. Alkali-treated collagen retained the triple helical conformation and the ligand activity for the cell adhesion via alpha2beta1 integrin. J Biochem. 125, 676-684 (1999) PubMed PMID: 10101279

Suzuki Y, Someki I, Adachi E, Irie S, Hattori S. Interaction of collagen molecules from the aspect of fibril formation: acid-soluble, alkali-treated, and MMP1-digested fragments of type I collagen. J Biochem. 126, 54-67 (1999) PubMed PMID: 10393321

Fujisaki H, Hattori S. Gelatin-binding immunoglobulins in normal bovine serum. Connect Tissue. 31, 155-160 (1999) Link

Sakaguchi M, Hori H, Hattori S, Irie S, Imai A, Yanagida M, Miyazawa H, Toda M, Inouye S. IgE reactivity to alpha1 and alpha2 chains of bovine type 1 collagen in children with bovine gelatin allergy. J Allergy Clin Immunol. 104, 695-699 (1999) PubMed PMID: 10482848

Miura Y, Arai T, Ohtake A, Ito M, Yamamoto K, Yamagata T. Requirement for a different hydrophobic moiety and reliable chromogenic substrate for endo-type glycosylceramidases. Glycobiology. 9, 957-960 (1999) PubMed PMID: 10460837

Nagaya H, Ymagata T, Ymagata S, Iyoda K, Ito H, Hasegawa Y, Iwata H. Examination of synovial fluid and serum hyaluronidase activity as a joint marker in rheumatoid arthritis and osteoarthritis patients (by zymography). Ann Rheum Dis. 58, 186-188 (1999) PubMed PMID: 10364918

Hyuga S, Yamagata S, Takatsu Y, Hyuga M, Nakanishi H, Furukawa K, Yamagata T. Suppression by ganglioside GD1A of migration capability, adhesion to vitronectin and metastatic potential of highly metastatic FBJ-LL cells. Int J Cancer. 83, 685-691 (1999) PubMed PMID: 10521808

Hirayama N, Miura Y, Iijima K, Ohya K, Irie S, Fujimoto D. Increased urinary excretion of pyridinium crosslinks in streptozotocin-induced diabetic rats. Biomed Res. 20, 133-140 (1999) DOI: 10.2220/biomedres.20.133

Katagiri K, Yokosawa H, Kinashi T, Kawashima S, Irie S, Tanaka K, Katagiri T. Ubiquitin-proteasome system is involved in induction of LFA-1/ICAM-1-dependent adhesion of HL-60 cells. J Leukoc Biol. 65, 778-785 (1999) PubMed PMID: 10380899

Sato K, Katagiri K, Hattori S, Tsuji T, Irimura T, Irie S, Katagiri T. Laminin 5 promotes activation and apoptosis of the T cells expressing alpha3beta1 integrin. Exp Cell Res. 247, 451-460 (1999) PubMed PMID: 10066373


Shirai T, Hattori S, Sakaguchi M, Inouye S, Kimura A, Ebihara T, Irie S, Nagai Y, Hori H. The complete cDNA coding sequence for the bovine proalpha2(I) chain of type I procollagen. Matrix Biol. 17, 85-88 (1998) PubMed PMID: 9628255

Koyama Y, Kusubata M, Yoshiki A, Hiraiwa N, Ohashi T, Irie S, Kusakabe M. Effect of tenascin-C deficiency on chemically induced dermatitis in the mouse. J Invest Dermatol. 111, 930-935 (1998) PubMed PMID: 9856798

Ogawa-Goto K, Arao Y, Ito Y, Ogawa T, Abe T, Kurata T, Irie S, Akanuma H. Binding of human cytomegalovirus to sulfated glucuronyl glycosphingolipids and their inhibitory effects on the infection. J Gen Virol. 79 ( Pt 10), 2533-2541 (1998) PubMed PMID: 9780061

Kobayashi T, Hattori S, Nagai Y, Tajima S, Nishikawa T. Differential regulation of MMP-2 and MMP-9 gelatinases in cultured human keratinocytes. Dermatology. 197, 1-5 (1998) PubMed PMID: 9693177

Nakajima H, Miura Y, Yamagata T. Glycosylation of amphipathic lactoside primers with consequent inhibition of endogenous glycosphingolipid synthesis. J Biochem. 124, 148-156 (1998) PubMed PMID: 9644257

Ji L, Ito M, Zhang G, Hirabayashi Y, Inokuchi J, Yamagata T. Effects of endoglycoceramidase or D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol on glucose uptake, glycolysis, and mitochondrial respiration in HL60 cells. Arch Biochem Biophys. 359, 107-114 (1998) PubMed PMID: 9799567

Ogawa-Goto K, Abe T. Gangliosides and glycosphingolipids of peripheral nervous system myelins--a minireview. Neurochem Res. 23, 305-310 (1998) PubMed PMID: 9482242


Kobayashi T, Hattori S, Nagai Y, Sakuraoka K, Nishikawa T. Secretion of different types of gelatinases from cultured human keratinocytes. J Dermatol. 24, 213-216 (1997) PubMed PMID: 9164060

Kobayashi T, Konohana A, Hattori S. A case of linear IgA disease: an immunofluorescent study using confocal laser scan microscopy. J Dermatol. 24, 306-309 (1997) PubMed PMID: 9198319

Watanabe K, Nakagawa J, Ebihara T, Okamoto Y. Effects of the methylene chain length of chemically introduced crosslinks on the properties of collagen. Polymer. 38, 5155-5159 (1997) DOI: 10.1016/S0032-3861(97)00046-3

Watanabe K. Comparison of properties of the collagen cross-linked with aliphatic or aromatic reagent. Polym J. 29, 286-289 (1997) DOI: 10.1295/polymj.29.286

Watanabe K, Tezuka Y, Ishii T. Configuration between re-formed collagen triple helices and artificially introduced cross-links in gelatin gels. Macromolecules. 30, 7910-7913 (1997) DOI: 10.1021/ma9707392

Watanabe K, Muto K, Ishii T. Conformational analysis of poly(L-tyrosine) and tyrosyl oligomers based on backbone circular dichroism spectra obtained by fluorescence-detected circular dichroism. Biospectroscopy. 3, 103-111 (1997) DOI: 10.1002/(SICI)1520-6343(1997)3:2<103::AID-BSPY3>3.0.CO;2-8


Sasaki T, Hori H, Arai K, Hattori S, Nagai Y. Effects of a factor derived from polymorphonuclear leukocytes on the growth and collagen metabolism in normal and scleroderma skin fibroblast cultures. J Dermatol Sci. 11, 10-18 (1996) PubMed PMID: 8867762

Hattori S, Sakai K, Watanabe K, Fujii T. The induction of metachromasia and circular dichroism of coomassie brilliant blue R-250 with collagen and histone H1 is due to the low content of hydrophobic amino acid residues in these proteins. J Biochem. 119, 400-406 (1996) PubMed PMID: 8830031

Kobayashi T, Onoda N, Takagi T, Hori H, Hattori S, Nagai Y, Tajima S, Nishikawa T. Immunolocalizations of human gelatinase (type IV collagenase, MMP-9) and TIMP (tissue inhibitor of metalloproteinases) in normal epidermis and some epidermal tumors. Arch Dermatol Res. 288, 239-244 (1996) PubMed PMID: 8738566

Kobayashi T, Sakuraoka K, Hattori S, Hori H, Nagai Y, Tajima S, Nishikawa T. Immunolocalization of human gelatinase (type IV collagenase, MMP-9) and tissue inhibitor of metalloproteinase 1 in Hailey-Hailey and Darier's diseases. Dermatology. 193, 110-114 (1996) PubMed PMID: 8884145

Mizuta T, Shimada H, Arai K, Hori H, Hattori S, Yamamoto K, Sakai T, Nagai Y. Characterization of monoclonal antibodies recognizing human merosin and their use in affinity purification of native merosin. Hybridoma. 15, 373-378 (1996) PubMed PMID: 8913787

Hattori S, Fujisaki H. Double immunodetection of proteins transferred onto a membrane using two different chemiluminescent reagents. Anal Biochem. 243, 277-279 (1996) PubMed PMID: 8954561

Sakai K, Fujii T, Hayashi T. Conformational change precedes the formation of multimeric fibronectin. J Biochem. 119, 58-62 (1996) PubMed PMID: 8907176

Koyama Y, Norose K, Kusubata M, Irie S, Kusakabe M. Differential expression of tenascin in the skin during hapten-induced dermatitis. Histochem Cell Biol. 106, 263-273 (1996) PubMed PMID: 8897067

Koyama Y, Marunouchi T. Macrophage colony-stimulating factor (M-CSF) inhibits the decrease in the amount of rRNA and IA beta mRNA in cultured epidermal Langerhans cells of the mouse. J Dermatol. 23, 73-82 (1996) PubMed PMID: 8839232

Kuwaba K, Fujii T. Identification of type III collagen-derived polymeric components in commercial lime-processed hide gelatins. J Photogr Sci. 44, 62-65 (1996) DOI: 10.1080/00223638.1996.11737635

Matsubara M, Kusubata M, Ishiguro K, Uchida T, Titani K, Taniguchi H. Site-specific phosphorylation of synapsin I by mitogen-activated protein kinase and Cdk5 and its effects on physiological functions. J Biol Chem. 271, 21108-21113 (1996) PubMed PMID: 8702879

Watanabe K, Nakagawa J, Ebihara T, Okamoto Y. Structural effects of cross-linking reagents on triple-helix reformation of intramolecularly cross-linked collagen. Polymer. 37, 1285-1288 (1996) DOI: 10.1016/0032-3861(96)80856-1

Katagiri K, Kinashi T, Irie S, Katagiri T. Differential regulation of leukocyte function-associated antigen-1/ intercellular adhesion molecules-1-dependent adhesion and aggregation in HL-60 cells. Blood. 87, 4276-4285 (1996) PubMed PMID: 8639786

Katagiri K, Yokoyama KK, Yamamoto T, Omura S, Irie S, Katagiri T. Lyn and Fgr protein-tyrosine kinases prevent apoptosis during retinoic acid-induced granulocytic differentiation of HL-60 cells. J Biol Chem. 271, 11557-11562 (1996) PubMed PMID: 8626717


Arai T, Kusubata M, Kohsaka T, Shiraiwa M, Sugawara K, Takahara H. Mouse uterus peptidylarginine deiminase is expressed in decidual cells during pregnancy. J Cell Biochem. 58, 269-278 (1995) PubMed PMID: 7593250

Kaneko Y, Igarashi M, Iwashita M, Suzuki K, Kojima H, Kimura S, Hasobe M. Effects of fish and calf type I collagens as culture substrate in the adhesion and spreading process of established fish cells. In Vitro Cell Dev Biol Anim. 31, 178-182 (1995) PubMed PMID: 7757299

Sasagawa Y, Izaki K, Matsubara Y, Suzuki K, Kojima H, Kamio Y. Molecular cloning and sequence analysis of the gene encoding the collagenase from Cytophaga sp. L43-1 strain. Biosci Biotechnol Biochem. 59, 2068-2073 (1995) PubMed PMID: 8541644


Sakai K, Fujii T, Hayashi T. Cell-free formation of disulfide-bonded multimer from isolated plasma fibronectin in the presence of a low concentration of SH reagent under a physiological condition. J Biochem. 115, 415-421 (1994) PubMed PMID: 8056752

Katagiri K, Hattori S, Nakamura S, Yamamoto T, Yoshida T, Katagiri T. Activation of Ras and formation of GAP complex during TPA-induced monocytic differentiation of HL-60 cells. Blood. 84, 1780-1789 (1994) PubMed PMID: 7521689

Jung SK, Fujimoto D. A novel beta-galactoside-binding lectin in adult rat kidney. J Biochem. 116, 547-553 (1994) PubMed PMID: 7852273

Yamamoto T, Akasaka K, Irie S, Shimada H. A long polypyrimidine:polypurine sequence in 5' flanking region of arylsulfatase gene of sea urchin embryo. Int J Dev Biol. 38, 337-344 (1994) PubMed PMID: 7981042

Niwa J, Kobayashi M, Koyama Y, Kotani H, Mitsudo K, Hoshino T. Langerhans cells closely associated with Thy-1-positive dendritic cells in the stratified squamous mucosal epithelium of mice. Arch Histol Cytol. 57, 259-266 (1994) PubMed PMID: 7818949

Kurosaka D, Hattori S, Hori H, Yamaguchi N, Hasegawa T, Akimoto H, Nagai Y. Substitution of cysteine for glycine-946 in the alpha 1(I) chain of type I procollagen causes lethal osteogenesis imperfecta. J Biochem. 115, 853-857 (1994) PubMed PMID: 7961597

Fujita H, Jung SK, Mukainaka Y, Tachikawa H, Fujimoto D, Kosuge T, Shirai T, Takeiri A, Suzuki Y. Characterization of natural IgG antibody with anti-beta-galactosyl specificity. Biomed Res. 15, 17-25 (1994) DOI: 10.2220/biomedres.15.17

Kotani M, Hosoya H, Kubo H, Itoh K, Sakuraba H, Kusubata M, Inagaki M, Yazaki S, Suzuki Y, Tai T. Evidence for direct binding of intracellularly distributed ganglioside GM2 to isolated vimentin intermediate filaments in normal and Tay-Sachs disease human fibroblasts. Cell Struct Funct. 19, 81-87 (1994) PubMed PMID: 7923401

Tsujimura K, Tanaka J, Ando S, Matsuoka Y, Kusubata M, Sugiura H, Yamauchi T, Inagaki M. Identification of phosphorylation sites on glial fibrillary acidic protein for cdc2 kinase and Ca(2+)-calmodulin-dependent protein kinase II. J Biochem. 116, 426-434 (1994) PubMed PMID: 7822264


Kuwaba K, Fujii T. Attachment and spreading of the murine transformed keratinocyte cell line PAM 212 on fibronectin. Connect Tissue. 25, 167-181 (1993) Link

Kobayashi T, Hori H, Kanamori T, Hattori S, Takagi T, Watanabe H, Nishikawa T, Nagai Y. Monoclonal antibodies to human polymorphonuclear leukocyte gelatinase (type IV collagenase) are cross-reactive with fibroblast gelatinase. Biochem Biophys Res Commun. 193, 490-496 (1993) PubMed PMID: 8390241

Sasagawa Y, Kamio Y, Matsubara Y, Matsubara Y, Suzuki K, Kojima H, Izaki K. Purification and properties of collagenase from Cytophaga sp. L43-1 strain. Biosci Biotechnol Biochem. 57, 1894-1898 (1993) PubMed PMID: 7764338