Taga Y, Kusubata M, Ogawa-Goto K, Hattori S. Efficient Absorption of X-Hydroxyproline (Hyp)-Gly after Oral Administration of a Novel Gelatin Hydrolysate Prepared Using Ginger Protease. J Agric Food Chem. 2016 Apr 13;64(14):2962-70 [PubMed]

Terajima M, Taga Y, Chen Y, Cabral WA, Hou-Fu G, Srisawasdi S, Nagasawa M, Sumida N, Hattori S, Kurie JM, Marini JC, Yamauchi M. Cyclophilin-B Modulates Collagen Cross-linking by Differentially Affecting Lysine Hydroxylation in the Helical and Telopeptidyl Domains of Tendon Type I Collagen. J Biol Chem. 2016 Apr 29;291(18):9501-12

Qian J, Okada Y, Ogura T, Tanaka K, Hattori S, Ito S, Satoh J, Takita T, Yasukawa K. Kinetic analysis of the digestion of bovine type I collagen telopeptides with porcine pepsin. J Food Sci. (2016) 81(1): C27-34 [PubMed]

Wang HJ, Li MQ, Liu W, Yao GD, Xia MY, Hayashi T, Fujisaki H, Hattori S, Tashiro SI, Onodera S, Ikejima T. Gelatin promotes murine fibrosarcoma L929 cell detachment and protects the cells from TNFα-induced cytotoxicity. Connective Tissue Research, (2016) in press [PubMed]

Taga Y, Kusubata M, Ogawa-Goto K, Hattori S. Developmental stage-dependent regulation of prolyl 3-hydroxylation in tendon type I collagen. J. Biol. Chem., (2016) 291:837-847

Sekiguchi H, Uchida K, Inoue G, Matsushita O, Saito W, Aikawa J, Tanaka K, Fujimaki H, Miyagi M, Takaso M. Acceleration of bone formation during fracture healing by poly(Pro-Hyp-Gly)10 and basic fibroblast growth factor containing polycystic kidney disease and collagen-binding domains from Clostridium histolyticum collagenase. J Biomed Mater Res A. (2016) 104(6):1372-8 [PubMed]


Nakayama H, Tanaka K, Teramura N, Hattori S. Expression of collagenase in Flavobacterium psychrophilum isolated from cold-water disease-affected ayu (Plecoglossus altivelis). Biosci Biotechnol Biochem. (2015) 80(1): 135-44

Hirose T, Ogura T, Tanaka K, Minaguchi J, Yamauchi T, Fukada T, Koyama Y, Takehana K. Comparative study of dermal components and plasma TGF-β1 levels in Slc39a13/Zip13-KO mice. J Vet Med Sci. (2015) 77(11): 1385-9

Watanabe T, Nishimura K, Takeuchi R, Koyama Y, Kusubata M, Takehana K, Hiramatsu K. Oral ingestion of collagen peptide causes change in width of the perimysium of the chicken iliotibialis lateralis muscle. J Vet Med Sci (2015) 77(11):1413-1417

Terao K, Kanenaga R, Yoshida T, Mizuno K, Bächinger HP. Temperature induced complex formation-deformation behavior of collagen model peptides and polyelectrolytes in aqueous solution. Polymer, (2015) 64:8-13

Koyama Y, Kuwaba K, Kusubata M, Hayashida O, Takara T, Tsukada Y. Supplemental ingestion of collagen peptide improves T-cell-related human immune status. Jap Pharmacol Ther 43:51-56 (2015)

Ohno M, Ito K, Lan VTT, Kusubata M, Tometsuka C, Koyama Y, Motoyama T, Ito S, Kawarasaki Y. Trp-Arg-Glu synergistically inhibits human dipeptidyl peptidase IV with Gly-Pro-Ala, a constituent tripeptide of collagen hydrolysates. Peptides (in press)

Kusubata M, Koyama Y, Tometsuka C, Shigemura Y, Sato K. Detection of endogenous and food-derived collagen dipeptide prolylhydroxyproline (Pro-Hyp) in allergic dermatitis-affected mouse ear. Biosci Biotechnol Biochem 79:1356-61 [PubMed]

Kobayashi, K., Maehata, Y., Okada, Y., Kusubata, M., Hattori, S., Tanaka, K., Miyamoto, C., Yoshino, F., Yoshida, A., Tokutomi, F., Wada-Takahashi, S, Komatsu, T., Otsuka, T., Takahashi, S., Lee, M. Medical-grade collagen peptide in injectables provides antioxidant protection. Pharm. Dev. Technol. (2015) 20: 219-226.

Wang HJ, He WQ, Chen L, Liu WW, Xu Q, Xia MY, Hayashi T, Fujisaki H, Hattori S, Tashiro S, Onodera S, Ikejima T. Type I collagen gel protects murine fibrosarcoma L929 cells from TNFα-induced cell death. Biochem Biophys Res Commun. (2015) 457:693-699


Iijima K, Sasaki M, Taga Y, Hattori S. Cross conversion between Nω-carboxymethylarginine (CMA) and glyoxal derived hydroimidazolones (G-Hs). IMARS Highlights., (2014) 9:29-36 [link]

Noritake, K., Kuroda, S., Nyan, M., Atsuzawa, Y., Uo, M., Ohya, K., Kasugai, S. Use of a gelatin hydrogel membrane containing β-tricalcium phosphate for guided bone regeneration enhances rapid bone formation. Dent Mater J. (2014) 33: 674-80

Taga Y, Kusubata M, Ogawa-Goto K, Hattori S. Highly accurate quantification of hydroxyproline-containing peptides in blood using a protease digest of stable isotope-labeled collagen. J. Agric. Food Chem., (2014) 62:12096-102

Taga Y, Kusubata M, Ogawa-Goto K, Hattori S. Stable isotope-labeled collagen: a novel and versatile tool for quantitative collagen analyses using mass spectrometry. J. Proteome Res, (2014) 13: 3671-78

Koyama Y, Kuwaba K, Kondo S, Tsukada Y. Supplemental ingestion of collagen peptide suppresses ultraviolet-induced erythema. – a randomized double-blind placebo-controlled study –. Jap Pharmacol Ther (2014) 42:781-790

Shibuya S, Ozawa Y, Toda T, Watanabe K, Tometsuka C, Ogura T, Koyama Y, Shimizu T. Collagen peptide and vitamin C additively attenuate age-related skin atrophy in Sod1-deficient mice. Biosci Biotechnol Biochem (2014) 78:1212-1220

Saito, W, Uchida, K., Ueno, M, Matsushita, O, Inoue, G, Nishi, N, Ogura, T, Hattori, S, Fujimaki, H., Tanaka, K, Takaso, M. Acceleration of bone formation during fracture healing by injectable collagen powder and human basic fibroblast growth factor containing a collagen-binding domain from Clostridium histolyticum collagenase. J Biomed Mater Res A., (2014) 102:3049-55 [PubMed]

Uchida, K., Matsushita, O., Naruse, K., Mima, T., Nishi, N., Hattori, S., Ogura, T., Inoue, G., Tanaka, K., Takaso, M. Acceleration of periosteal bone formation by human basic fibroblast growth factor containing a collagen-binding domain from Clostridium histolyticum collagenase. J Biomed Mater Res A., (2014) 102:1737-43 [PubMed]

Shibuya S, Ozawa Y, Toda T, Watanabe K, Tometsuka C, Ogura T, Koyama Y, and Shimizu T. Collagen Peptide and Vitamin C Additively Attenuate Age-Related Skin Atrophy in Sod1-Deficient Mice. Biosci. Biotechnol. Biochem. (2014) 78:1212-20 [PubMed]


Taga Y, Kusubata M, Ogawa-Goto K, Hattori S. Site-specific quantitative analysis of overglycosylation of collagen in osteogenesis imperfecta using hydrazide chemistry and SILAC. J Proteome. Res., (2013) 12: 2225-32

Ushiki-Kaku Y, Shimizu Y, Tabeta N, Iwamaru Y, Ogawa-Goto K, Hattori S, Yokoyama T. Heterogeneity of abnormal prion protein (PrPSc) in murine scrapie prions determined by PrPSc-specific monoclonal antibodies. J Vet Med Sci., (2013) 76:285-288

Ushiki-Kaku Y, Iwamaru Y, Masujin K, Imamura M, Itohara S, Ogawa-Goto K, Hattori S, Yokoyama T. Different antigenicities of the N-terminal region of cellular and scrapie prion proteins. Microbiol Immunol., (2013) 57:792-6

Yamamoto T, Ushiki-Kaku Y, Yokoyama T, Hattori S. Sensitivity and specificity of a commercial BSE kit for the detection of ovine scrapie. Anim Sci J., (2013) 84:508-12

Pokidysheva E, Zientek KD, Ishikawa Y, Mizuno K, Vranka JA, Montgomery NT, Keene DR, Kawaguchi T, Okuyama K, Bächinger HP. Posttranslational modifications in type I collagen from different tissues extracted from wild type and prolyl 3-hydroxylase 1 null mice. J Biol Chem., (2013) 288:24742-52

Okuyama K, Kawaguchi T, Shimura M, Noguchi K, Mizuno K, Bächinger HP. Crystal structure of the collagen model peptide (Pro-Pro-Gly)4-Hyp-Asp-Gly- (Pro-Pro-Gly)4 at 1.0 Å resolution. Biopolymers, (2013) 99:436-47

Mizuno K, Boudko S, Engel J, Bächinger HP. Vascular Ehlers-Danlos syndrome mutations in type III collagen differently stall the triple helical folding. J Biol Chem., (2013) 288:19166-76

Koyama Y and Kusubata, M. Effects of Collagen Peptide Ingestion on Blood Lipids in Rats Fed a High-Lipid and High-Sucrose Diet. Food Sci. Technol. Res. 19(6):1149-1153 (2013)

Yuda,Y., Kasashima, Y., Kuwano, A., Sato , K., Hattori, S. and Arai, K. Active Hyaluronidase 2 Expression in the Granulation Tissue Formed in the Healing Process of Equine Superficial Digital Flexor Tendonitis (note)—.The Journal of Veterinary Medical Science 75:219–223 (2013)


Ogawa-Goto K, Ueno T, Oshima K, Yamamoto H, Sasaki J, Fujita K, Sata T, Taniguchi S, Kanda Y, Katano H. Detection of Active Human Cytomegalovirus by the Promyelocytic Leukemia Body Assay in Cultures of PBMCs From Patients Undergoing Hematopoietic Stem Cell Transplantation. J Med Virol 84:479-486 (2012)

Yamamoto T, Nakashima K, Maruta Y, Kiriyama T, Sasaki M, Sugiyama S, Suzuki K, Fujisaki H, Sasaki J, Kaku UY, Tanida M, Irie S, Hattori S. Improved RNA Extraction Method Using the BioMasher and BioMasher Power-Plus. J Vet. Med. Sci. 74:1561-67 (2012)

Takahashi T, Kondo T, Tanaka K, Hattori S, Irie S, Kudoh S, Imura S, Kanda H. Measurement of solar UV radiation in Antarctica with collagen sheets. Photochem Photobiol Sci. 11(7):1193-200 (2012)

Ueno T, Kaneko K, Sata T, Hattori S, Ogawa-Goto K. "Regulation of polysome assembly on the endoplasmic reticulum by a coiled-coil protein, p180. Nucleic Acids Res. 40(7): 3006-3017 (2012)

Taga Y, Kusubata M, Ogawa-Goto K, Hattori S. Development of a novel method for analyzing collagen O-glycosylations by hydrazide chemistry. Mol Cell Proteomics. 11(6): M111 010397 (2012)


Teramura N, Tanaka K, Iijima K, Hayashida O, Suzuki K, Hattori S, Irie S. Cloning of a novel collagenase gene from Gram-negative bacterium Grimontia (Vibrio) hollisae 1706B and its efficient expression in Brevibacillus choshinensis. J Bacteriol. 193:3049-56 (2011)

Kobayashi K, Maehata Y, Kawamura Y, Kusubata M, Hattori S, Tanaka K, Miyamoto C, Yoshino F, Yoshida A, Wada-Takahashi S, Komatsu T, Takahashi SS, Lee MC. Direct assessments of the antioxidant effect of the novel collagen peptide on reactive oxygen species using electron spin resonance spectroscopy. J Pharmacol Sci. 116: 97-106 (2011)

Ueno T, Kaneko K, Sata T, Hattori S, Ogawa-Goto K. Regulation of polysome assembly on the endoplasmic reticulum by a coiled-coil protein, p180. Nucleic Acids Res. (2011)

Sasaki J, Fujisaki H, Adachi E, Irie S, Hattori S. Delay of cell cycle progression and induction of death of cancer cells on type I collagen fibrils. Connect Tissue Res. (2011)


omonori Ueno, Keisuke Tanaka, Keiko Kaneko, Yuki Taga, Tetsutaro Sata, Shinkichi Irie, Shunji Hattori, Kiyoko Ogawa-Goto. Enhancement of procollagen biosynthesis by p180 through augmented ribosome association on the endoplasmic reticulum in response to stimulated secretion. Journal of Biological Chemistry, 285, 29941-29950, (2010)

Ushiki-Kaku Y, Endo R, Iwamaru Y, Shimizu Y, Imamura M, Masujin K, Yamamoto T, Hattori S, Itohara S, Irie S, Yokoyama T. Tracing conformational transition of abnormal prion proteins during interspecies transmission by using novel antibodies. J Biol Chem.  285(16):11931-6 (2010)

Shimizu Y, Kaku-Ushiki Y, Iwamaru Y, Muramoto T, Kitamoto T, Yokoyama T, Mohri S, Tagawa Y. A novel anti-prion protein monoclonal antibody and its single-chain fragment variable derivative with ability to inhibit abnormal prion protein accumulation in cultured cells. Microbiol Immunol. 54(2):112-21 (2010)

Hosseinkhani H, Hosseinkhani M, Hattori S, Matsuoka R, Kawaguchi N. Micro and nano-scale in vitro 3D culture system for cardiac stem cells. J Biomed Mater Res A. 2010 94(1):1-8. (2010)

Yonezawa T, Hattori S, Inagaki J, Kurosaki M, Takigawa T, Hirohata S, Miyoshi T, Ninomiya Y. Type IV collagen induces expression of thrombospondin-1 that is mediated by integrin alpha1beta1 in astrocytes. Glia. 58,755-767 (2010)

Fujita K, Teramura N, Hattori S, Irie S, Mitsunaga-Nakatsubo K, Akimoto Y, Sakamoto N, Yamamoto T, Akasaka K. Mammalian arylsulfatase A functions as a novel component of the extracellular matrix. Connect Tissue Res. 51,388-396 (2010)

Li S, Shimono C, Norioka N, Nakano I, Okubo T, Yagi Y, Hayashi M, Sato Y, Fujisaki H, Hattori S, Sugiura N, Kimata K, Sekiguchi K. Activin a binds to perlecan through its pro-region that has heparin/heparan sulfate-binding activity. J Biol Chem.  285, 36645-55.(2010)

T. Ueno, K. Kaneko, H. Katano, Y. Sato, R. Mazitschek, K. Tanaka, S. Hattori, S. Irie, T. Sata, K. Ogawa-Goto. Expansion of the trans-Golgi network following activated collagen secretion is supported by a coiled-coil microtubule-bundling protein, p180, on the ER. Exp Cell Res. 316(3): 329-340 (2010)


K. Tanaka, T. Ebihara, M. Kusubata, E. Adachi, M. Arai, N. Kawaguchi, J. Utsunomiya, Y. Miki, M. Hiramoto, S. Hattori, S. Irie. Abnormal collagen deposition in fibromas from patient with juvenile hyaline fibromatosis. J Dermatol Sci. 55(3): 197-200 (2009)

Ueno T, Ogawa-Goto K. Use of a GFP-PML-expressing cell line as a biosensor for human cytomegalovirus infection. Methods Mol Biol. 515: 33-44 (2009)


Iwamaru Y, Shimizu Y, Imamura M, Murayama Y, Endo R, Tagawa Y, Ushiki- Kaku Y, Takenouchi T, Kitani H, Mohri S, Yokoyama T, Okada H. Lactoferrin induces cell surface retention of prion protein and inhibits prion accumulation. J Neurochem. 2008 Nov;107(3):636-46.

Fujisaki H., Adachi, E and Hattori S. Keratinocyte differentiation and proliferation are regulated by adhesion to the three-dimensional meshwork structure of type IV collagen. Connective Tissue Research  49, 426-436 (2008)

Yamamoto T, Ushiki Y, Hara S, Hall, W.W, Tsukagoshi-Nagai, H, Yokoyama ,T. Tagawa,Y., Sata, T., Yamakawa,Y., Kinoshita, N., Hattori S., and Irie S. An advantageous method utilizing new homogenizing device BioMasher and a sensitive ELISA to detect bovine spongiform encephalopathy accurately from brain tissue. J Virol. Methods. 149.316-325 (2008)


Kitamori, K., Kobayashi, M., Akamatsu, H., Hirota-Sakashita, A., Kusubata, M., Irie,S., Koyama, Y. Weakness of intercellular association of keratinocytes in severely brittle nails. ArchivesHistology and Cytology69(5) p.323-328 (2007)

Fujisaki, H., Ebihara, T., Irie,S., Kobayashi, T., Adachi, E., Mochitate, K., Hattori,S. . Keratinocyte apoptosis on type I collagen fibrils is prevented by Erk1/2 activation under high calcium condition.Connective Tissue Research(in press)

Sano, K., Asanuma-Date, K., Arisaka, F., Hattori, S., Ogawa ,H. Changes in glcosylation in vitronectin modulate multimerization and collagen binding during liver regeneration..Glycobiology. (in press)

Iijima K, Fujimoto D, Irie S. Amount of N(omega)-(Carboxymethyl)arginine generated in collagen and bovine serum albumin during glycation reactions is significantly different. Connect Tissue Res. 48(5): 271-276 (2007)

Ogawa-Goto K, Tanaka K, Ueno T, Kurata T, Sata T, Irie S. "p180 is involved in the interaction between the endoplasmic reticulum and microtubules through a novel microtubule-binding and bundling domain. Mol Biol Cell. 18(10): 3741-3751 (2007)


Matsuda, N., Koyama, Y., Hosaka, Y., Ueda, H., Watanabe, T., Araya, T., Irie, S., Takehana, K.Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis. J. Nutr. Sci. Vitaminol. 52, 211-215 (2006)

Ueno T, Eizuru Y, Katano H, Kurata T, Sata T, Irie S, Ogawa-Goto K.Novel real-time monitoring system for human cytomegalovirus-infected cells in vitro that uses a green fluorescent protein-PML-expressing cell line.Antimicrob Agents Chemother. 50(8) 2806-13 (2006)

Ino T., Hattori, M., Yoshida, T., Hattori, S., Yoshimura, K. and Takahashi, K. Improved physical and biochemical features of a collagen membrane by conjugating with soluble egg shell membrane protein. Biosci. Biotechnol. Biochem, 70, 865-873 (2006)


Hayashi, HK., Yokoyama, T., Takata, M., Iwamaru, Y., Imamura, M., Ushiki, YK. and Shinagawa, M. The N-terminal cleavage site of PrPSc from BSE differs from that of PrPSc from scrapie. Biochem. Biophys. Res. Commun. 328 1024-1027 (2005)

Miura-Yokota, Y., Matsubara, Y., Ebihara, T., Koyama, Y., Ogawa-Goto, K., Isobe, N., Hattori, S. and Irie, S. Cloning and nucleotide sequence of a novel 28-kDa protein from the mantle muscle of the squid Todarodes pacificus with homology to tropomyosin. Comp. Biochem. Physiol. B 141, 3-12 (2005)

Minaguchi, J., Koyama, Y., Meguri, N., Hosaka, Y., Ueda, H., Kusubata, M., Hirota, A., Irie, S., Mafune, N., Takehana, K. Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in Achilles tendon.J. Nutr. Sci. Vitaminol. 51 169-174 (2005)


Kajimura, D., Takahashi, S., Yoshikawa, K., Hattori, S., Sado, Y., Imamura, Y. and Hayashi, T. Non-helical type IV collagen polypeptides in human placenta. Biochem. Biophys. Res. Commu. 314, 11-16 (2004)

Hayashi H, Iwamaru Y, Takata M, Ushiki Y, Imamura M, Yokoyama T, Shinagawa M. Effect of tissue deterioration on postmortem BSE diagnosis by Immunobiochemical detection of an abnormal isoform of prion protein. J. Vet. Med. Sci. 66,515-520 (2004)

Miura-Yokota, Y., Matsubara, Y., Ebihara T., Hattori, S. and Irie, S. A Cysteine-Activated Protease Isolated from Todarodes Pacificus Squid Degrades Collagen Below its Denaturation Temperature. Connective Tissue Research 45 109-121 (2004)

Hirano, S., Yonezawa, T., Hasegawa, H., Hattori, S., Greenhill, NS., Davis, PF., Sage, EH. and Ninomiya, Y.Astrocytes express type VIII collagen during the repair process of brain cold injury. Biochem. Biophys. Res. Commun. 317 437-443 (2004)

Mimura, T., Yamagami, S., Yokoo, S., Usui, T., Tanaka, K., Hattori, S., Irie, S., Miyata, K.Araie, M., and Amano, S.Cultured Human Corneal Endothelial Cell Transplantation with a Collagen Sheet in a Rabbit Model. Investigative Ophthalmology and Visual Science 45 2992-2997 (2004)

Suzuki, Y., Hattori, S. and Isemura, M.Epigallocatechin-3-O-gallate Inhibits Fibroblast Contraction of Floating Collagen Gel: Interaction between Epigallocatechin-3-O-gallate and Platelet Derived Growth Factor. Biosci. Biotechnol. Biochem. 68 1817-1820 (2004)

Sato, K., Hattori, S., Irie, S., Sorimachi, H., Inomata. M. and Kawashima, S.Degradationoffodrinbym-calpaininfibroblastsadheringtofibrillarcollagen I gel. J. Biochem. 136 777-785 (2004)


Hirota, A., Ebihara, T., Kusubata, M., Kobayashi, M., Kobayashi, K., Kuwaba, K., Tanaka, K., Kiriyama, T., Irie, S., and Koyama, Y. Collagen of chronically inflamed skin is over-modified and upregulates secretion of matrix metalloproteinase 2 and matrix-degrqading enzymes by endothelial cells and fibroblasts. J Invest Dermatol 121:1317-1325 (2003)

Ogawa-Goto K, Tanaka K, Gibson W, Moriisihi E, Miura Y, Kurata T, Irie S and Sata T. Microtubule network facilitates nuclear targeting of human cytomegalovirus capsid. J.Virol.77: 8541-8547 (2003)

Kobayashi, T., Hattori, S. and Shinkai H. Matrix Metalloproteinases-2 and -9 are Secreted from Human Fibroblasts. Acta Dermato-Venereologica 83,105-107 (2003)

Sato, K., Hattori,S., Irie, S., and Kawashima, S. Spike formation by fibroblasts adhering to fibrillar collagen I gel. Cell Struc. Func. 28, 229-241 (2003)


Hattori,S., Fujisaki,H., Kiriyama, T., Yokoyama, T., and Irie, S. Real-time zymography and reverse zymography- A method for detecting activities of matrix metalloproteinases and their inhibitors using FITC-labeled collagen and casein as substrates. Anal. Biochm. 301, 27-34 (2002)

Ogawa-Goto,K, Irie S, Omori A, Miura Y, Katano H, Hasegawa H, Kurata T, Sata T, Arao Y. An Endoplasmic Reticulum Protein, p180, Is Highly Expressed in Human Cytomegalovirus-Permissive Cells and Interacts with the Tegument Protein Encoded by UL48. J. Virol. 76, 2350-2362 (2002)

Sugaya, M., Nakamura, K., Watanabe, T., Asashima, A., Yasaka, N., Koyama, Y., Kusubata, M., Ushiki, Y., Kimura, K., Morooka, A., Irie, S., Yokoyama, T., Inoue, K., Itohara, S., Tamaki, K. Expression of cellular prion-related protein by murine langerhans cells and keratinocytes. J. Dermatol. Sci. 28, 126-134 (2002)

Watanabe, K., and Hattori, S. Real-Time Dual Zymographic Analysis of Matrix Metalloproteinases Using FITC-Labeled Gelatin and Texas Red-Labeled Casein. Anal.Biochem. 307,390-392 (2002)

Hazeki N, Tsukamoto T, Yazawa I, Koyama M, Hattori S, Someki I, Iwatsubo T, Nakamura K, Goto J, and Kanazawa I. Ultrastructure of nuclear aggregates formed by expressing an expanded polyglutamine. Biochem Biophys Res Commun. 294, 429-440 (2002)

Hori, H., and Hattori, S., Inouye, S., Kimura, A., Irie, S., Miyazawa, H. and Sakaguchi, M. Analysis of major epitope of a2 chain of bovine type I collagen in children with bovine gelatin allergy. J. Allergy Clin. Immunol. 110,652-(2002)

Fujisaki, H. and Hattori, S. Keratinocyte apoptosis on Type I collagen gel caused by lack of laminin 5 /10/11 deposition and Akt signalling. Exp. Cell Res. 280, 255-269 (2002)

Kuwaba, K., Kobayashi, M., Nomura,,Y., Irie, S., and Koyama, Y. Size control of decorin dermatan sulfate during remodeling of collagen fibrils. in healing skin. J. Dermatol.Sci. 185-194 (2002)


Kajihara,T.,K., Hattori,S., and Irie,S. Type V collagen distribution in liver is reconstructed in coculture system of hepatocytes and stellate cells; possible function of type V collagen in liver under normal and pathological conditions. Cell Struc Func. 26 (5), 227-240 (2001)

Kobayashi,T., Nishikawa,T., Hattori,S., Yoshida,N.,Takagi,T., Watanabe, H., Hori, H.,Nagai,Y. Systematic Separation and Purification of Elastase, Gelatinase (Matrix Metalloproteinase 9), and Collagenase (Matrix Metalloproteinase 8) from Polymorphonuclear Leukocytes in Dialyzers Previously Used by Patients with Renal Failure. Protein Expression and Purification 22 , 45-51 (2001)

Kuwaba, K., Kobayashi, M., Nomura, Y., Irie, S., and Koyama, Y. Elongated dermatan sulfate in post-inflammatory healing skin distributes among collagen fibrils separated by enlarged interfibrillar gaps. Biochem, J. 358, 157-163 (2001)

Odani, H., Iijima, K., Nakata, M., Miyata, S., Kusunoki, H., Yasuda, Y., Hiki, Y., Irie, S., Maeda, K. and Fujimoto, D. Identification of N(omega)-carboxymethylarginine, a new advanced glycation endproduct in serum proteins of diabetic patients: possibility of a new marker of aging and diabetes. Biochem Biophys Res Commun. 285,5,1232-1236 (2001)

Nadanaka S, Sato C, Kitajima K, Katagiri K, Irie S, Yamagata T. Occurrence of oligosialic acids on integrin alpha 5 subunit and their involvement in cell adhesion to fibronectin. J Biol Chem. 276, 33657-33664 (2001)

Katano H, Ogawa-Goto K, Hasegawa H, Kurata T, Sata T. Human-herpesvirus-8-encoded K8 protein colocalizes with the promyelocytic leukemia protein (PML) bodies and recruits p53 to the PML bodies. Virology. 286, 446-455 (2001)

Yokoyama T, Kimura KM, Ushiki Y, Yamada S, Morooka A, Nakashiba T, Sassa T, Itohara S. In vivo conversion of cellular prion protein to pathogenic isoforms, as monitored by conformation-specific antibodies. J Biol Chem. 276, 11265-71. (2001)

Hyuga, S., Kawasaki, N., Ohta, M., Shibayama, R., Kawanishi, T., Yamagata, S., Yamagata, T., and Hayakawa, T. Ganglioside GD1a inhibits the HGF/SF-induced motility and scattering of cancer cells through suppression of tyrosine-phosphorylation of c-Met. International J. Cancer 94, 328-334 (2001)

Koyama Y, Hirota A, Mori H, Takahara H, Kuwaba K, Kusubata M, Matsubara Y, Kasugai S, Itoh M, Irie S. Ingestion of gelatin has differential effect on bone mineral density and body weight in protein undernutrition. J Nutr Sci Vitaminol (Tokyo). 47, 84-86. 2001

Tsuji-Yamada, J., Nakazawa, M., Takahashi, K., Iijima, K., Hattori, S., Okuda, K., 67) Minami, M., Ikezawa, Z., Sasaki, T. Effect of IL-12 Encoding Plasmid Administration on Tight-Skin Mouse. Biochem Biophys Res Commun 280, 707-712 (2001)


K.Katagiri, M. Hattori, N. Minato, S. Irie, K. Takatsu and T. Kinashi. Rap1 is a potent activation signal for LFA-1 distinct from PKC and PI3-kinase. Mol. Cell. Biol. 20, 1956-1969 (2000)

Watanabe, K., Takahashi, H., Habu, Y., Kamiya-Kubushiro, N., Kamiya, S., Nakamura, H., Yajima, H., Ishii, T., Katayama, T., Miyazaki, K., Fukai, F. Interaction with heparin and matrix metalloproteinase 2 cleavage expose acryptic anti-adhesive site of fibronectin. Biochemistry 39, 7138-44 (2000)

Sato, K., Ebihara, T., Adachi, E.,Kawashima, S., Hattori, S. and Irie, I. The reconstituted type I collagen fibrils from skins of variously aged bovines exert different effects on the morphology and integrin ?2?1 expression of fibroblasts in culture Connective Tissue 32, 1-10 (2000)

Sato, K., Ebihara, T., Adachi, E.,Kawashima, S., Hattori, S. and Irie, I. Possible involvment of aminotelopeptide in self-assembly and thermal stability of collagen I as revealed by its removal with proteases J. Biol. Chem. 275, 25870-25875 (2000)

Kobayashi, T., Hattori, S., Nagai, Y. and Tajima, S. Differential regulation of the secretions of matrix metalloproteinase (MMP)-9 and tissue inhibitor of metalloproreinases (TIMP)-1 from human keratinocyte in culture. IUBMB Life 50, 221-226 (2000)

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