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Collagen

Collagen is the most abundant protein in our body, about 30% of total protein. Collagen is rich in bone, skin, tendon, ligament, cartilage, heart, eye, and so on. Synthesis of collagen protein is one of the most complicated process among the all human proteins. Many enzymatically posttranslational modifications involve the synthesis such as 3- and 4-hydroxyproline and 5-hydroxylysine. Some of hydroxylysine residues are additionally modified as galactosylhydroxylysine and glucosylgalactosylhydroxylysine. 4-Hydroxylation of proline increases the thermal stability of triple helical structure. These posttranslational modification reactions are essential to the biological function. Defection of these enzymes causes abnormality in bone and other organs. Due to the many posttranslational modifications and the large size of molecule, it is impossible to produce collagen molecules from recombinant expression with reasonable prices. With Nippi’s more than a half century of research expertise, we produce purified collagen from various kinds of animal tissues such as skin, tendon, lens capsule, and cartilage. Bovine, porcine, chick, tilapia are some of the animal sources. Product forms are solution, powder, or sheets of reconstituted fibrils. Types I, III, and IV collagens are on our catalog list. We also accept custom orders for other types and/or from other animal sources. Please contact us if you need specific types of collagen, or if you would like to order in bulk.

Collagen solution

Collagen solution

We currently have bovine, porcine, chick and fish (Tilapia) collagen in our inventory. Types I, II, III, and IV collagens are available. For type I collagen, both acid soluble and pepsin solubilized are available from tendon and skin. Acid soluble collagen has noncollagenous telopeptides at both N- and C- terminal ends, and reconstitutes fibrils more close to native physiological collagen fibrils. Type II collagen is rich in articular cartilage, and recommended as the cartilage cell culture substrate. Type III collagen is abundant in dermis and aorta. In skin, about 80% of fibrillar collagen is type I, and the 15-20% is type III collagen. Type IV collagen is the major component of basement membrane. Our type IV collagen solution is made from bovine lens capsule with acid extraction. In contrast to usual pepsin solubilization method, our type IV collagen has the intact C-terminal noncollagenous NC1 domain and whole triple helical domain. Our type IV collagen forms three dimensional fine meshwork, similar to physiological basement membrane. We have the experience, knowledge, and skill regarding collagen protein extraction. Please check our catalog here . Custom orders from different animal species and different types of collagen are also available upon request. To some countries, bovine collagen might not be able to be exported. Please contact us for more details.

Collagen powder

Collagen powder

Nippi's patented technology enables the production of pure native triple helical collagen powder. Nippi’s collagen powder has a large surface area, and dissolves easily. This product is for research use only and is not intended for clinical use to human or other animals.

Collagen gel culture kit: Tri-D

Collagen gel culture kit: Tri-D

Tri-D is a kit for collagen gel cell culture. The kit includes collagen solution with 3x concentrated culture medium. This kit allows for convenient 3D collagen culture and is advantageous for the research of fibroblasts, osteoblasts, adipocytes, and mesenchymal stem cells.

Reconstituted Collagen Fibril Sheet Disk

Reconstituted Collagen Fibril Sheet Disk

Our collagen sheet resembles in vivo collagen fibril structure. The sheet is made from highly purified collagen. The density of collagen is approximately 20% after swelling, and is close to in vivo.

We are currently developing collagen for clinical grade. Please contact us for more details.

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